Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TXN | P10599 | 2/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ATP4A | P20648 | 1/20 | 0.41 |
| ▸ | ATP4B | P51164 | 1/20 | 0.41 |
| ▸ | MYC | P01106 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9514715 | 0.77 | POLB (0.71) | POLBSMN1; SMN2RAB9ANPC1ALDH1A1 | |
| SCHEMBL12368481 | 0.76 | POLB (1.00) | POLBSMN1; SMN2RAB9ANPC1TXN | |
| SCHEMBL10333546 | 0.74 | ALDH1A1 (0.60) | POLBSMN1; SMN2RAB9ANPC1ALDH1A1 | |
| SCHEMBL9512665 | 0.73 | POLB (0.65) | POLBSMN1; SMN2RAB9ANPC1ALDH1A1 | |
| SCHEMBL11687997 | 0.72 | POLB (0.63) | POLBSMN1; SMN2RAB9ANPC1TXN | |
| SCHEMBL6483534 | 0.71 | RAB9A (0.64) | SMN1; SMN2RAB9ANPC1ALDH1A1BCHE | |
| SCHEMBL9676124 | 0.71 | ATP4A (0.40) | POLBSMN1; SMN2RAB9ANPC1ALDH1A1 | |
| SCHEMBL10644621 | 0.70 | POLB (0.69) | POLBSMN1; SMN2RAB9ANPC1TXN | |
| SCHEMBL29888697 | 0.68 | SMN1; SMN2 (0.71) | POLBSMN1; SMN2RAB9AALDH1A1TXN | |
| SCHEMBL10352132 | 0.67 | POLB (0.70) | POLBSMN1; SMN2RAB9ANPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0174717-B1 | BENZIMIDAZOLES, AND THEIR PRODUCTION FORMULATION AND USE AS GASTRIC ACID SECRETION INHIBITORS | FISONS plc (GB) | 1992-01-22 | — | — | EP | disclosed |
| EP-0174717-A1 | Benzimidazoles, and their production formulation and use as gastric acid secretion inhibitors | FISONS plc (GB) | 1986-03-19 | — | — | EP | disclosed |