Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.61 |
| ▸ | CYP2A13 | Q16696 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4182979 | 0.80 | MAPK1 (0.57) | CYP2D6CYP2C19TP53MAPTSMN1; SMN2 | |
| SCHEMBL9742351 | 0.77 | KMT2A (0.50) | CYP3A4CYP2D6CYP2C19KCNH2ALDH1A1 | |
| SCHEMBL9514131 | 0.76 | ALDH1A1 (0.60) | HTTP2RX7DRD3KCNH2MAPT | |
| SCHEMBL9329794 | 0.76 | HTT (0.56) | HTTCYP2A13CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5542558 | 0.71 | CYP1A2 (0.52) | HTTCYP2A13CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4523295 | 0.71 | CYP1A2 (0.64) | CYP1A2CYP3A4CYP2D6CYP2C19P2RX7 | |
| SCHEMBL28958322 | 0.70 | ALDH1A1 (0.50) | HTTSMN1; SMN2ALDH1A1KDM4EPOLB | |
| SCHEMBL9511632 | 0.70 | HTT (0.59) | HTTTP53MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL4103976 | 0.69 | CYP2A13 (1.00) | HTTCYP2A13MAPTSMN1; SMN2SIGMAR1 | |
| SCHEMBL11360607 | 0.69 | SIGMAR1 (0.85) | HTTCYP2A13KCNH2TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0320910-B1 | 2-Thiazolidinone derivatives, pharmaceutical compositions containing them, process for preparing same, and use | RICHTER GEDEON VEGYESZET (HU) | 1993-12-08 | — | — | EP | disclosed |
| US-4937252-A | 2-thiazolidinone derivatives, pharmaceutical compositions containing them and process for preparing same | RICHTER GEDEON VEGYESZETI GYAR RT. (HU) | 1990-06-26 | — | — | US | disclosed |
| EP-0320910-A1 | 2-Thiazolidinone derivatives, pharmaceutical compositions containing them, process for preparing same, and use | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1989-06-21 | — | — | EP | disclosed |