Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | GSK3A | P49840 | 3/20 | 0.50 |
| ▸ | GSK3B | P49841 | 3/20 | 0.50 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.49 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9743263 | 0.85 | GRM2 (0.54) | MAPK1KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL9514131 | 0.85 | ALDH1A1 (0.60) | MAPK1ALDH1A1SIGMAR1MAPTHPGD | |
| SCHEMBL9742828 | 0.82 | ALDH1A1 (0.52) | ALDH1A1SIGMAR1HPGDKDM4ELMNA | |
| SCHEMBL28958322 | 0.82 | ALDH1A1 (0.50) | MAPK1KMT2APOLBALDH1A1KDM4E | |
| SCHEMBL9511632 | 0.82 | HTT (0.59) | KMT2AMEN1POLBALDH1A1MAPT | |
| SCHEMBL25002012 | 0.81 | CHRNA1 (0.60) | MAPK1GSK3AGSK3BDDB1CRBN | |
| Bromide SCHEMBL9512786 | 0.80 | CHRNA1 (0.59) | MAPK1GSK3AGSK3BDDB1CRBN | |
| SCHEMBL9512683 | 0.80 | HTT (0.61) | POLBCYP2D6CYP2C19ALDH1A1SIGMAR1 | |
| SCHEMBL9741850 | 0.78 | ALDH1A1 (0.49) | L3MBTL1POLBALDH1A1KDM4E | |
| SCHEMBL9743824 | 0.78 | ALDH1A1 (0.44) | MAPK1KMT2AMEN1CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1994014784-A1 | NEW THIAZOLIDINONE DERIVATIVES AND A PROCESS FOR THE PREPARATION THEREOF | Richter Gedeon Vegyészeti Gyár Rt. (HU) | 1994-07-07 | — | — | WO | claimed |
| EP-0320910-B1 | 2-Thiazolidinone derivatives, pharmaceutical compositions containing them, process for preparing same, and use | RICHTER GEDEON VEGYESZET (HU) | 1993-12-08 | — | — | EP | claimed |
| US-4937252-A | 2-thiazolidinone derivatives, pharmaceutical compositions containing them and process for preparing same | RICHTER GEDEON VEGYESZETI GYAR RT. (HU) | 1990-06-26 | — | — | US | claimed |
| EP-0320910-A1 | 2-Thiazolidinone derivatives, pharmaceutical compositions containing them, process for preparing same, and use | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1989-06-21 | — | — | EP | claimed |
| JP-2000279-A | — | — | None | — | — | JP | disclosed |
| CN-120157868-A | Thiazolidine ketone-based surfactant and preparation and application thereof | 南通理工学院 | 2025-06-17 | — | — | CN | disclosed |
| CN-110294719-B | Synthesis method of thiazolidone compound | 五邑大学 | 2023-02-28 | — | — | CN | disclosed |
| WO-2015027307-A1 | BENZYLTHIAZOLIDINONE DERIVATIVES USEFUL FOR THE TREATMENT OF SCHIZOPHRENIA | UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL-UFRGS (BR) | 2015-03-05 | — | — | WO | disclosed |
| US-20130165446-A1 | BENZO-OR PYRIDO-IMIDAZOLE DERIVATIVE | HORIKOSHI, HIROYOSHI (CA) | 2013-06-27 | — | — | US | disclosed |
| EP-2581373-A1 | BENZO- OR PYRIDO-IMIDAZOLE DERIVATIVE | Fujita, Takashi (JP) | 2013-04-17 | — | — | EP | disclosed |
| US-20090216024-A1 | Processes for making pioglitazone and compounds of the processes | ZHU JIE | 2009-08-27 | — | — | US | disclosed |
| US-7541470-B2 | Processes for making pioglitazone and compounds of the processes | SYNTHON IP INC. (US) | 2009-06-02 | — | — | US | disclosed |
| WO-2005080387-A2 | PROCESSES FOR MAKING PIOGLITAZONE AND COMPOUNDS OF THE PROCESSES | SYNTHON B.V. (NL) | 2005-09-01 | — | — | WO | disclosed |
| CN-1644579-A | N-alkoxide oxo-2-triazolidone derivative, its preparation and use | UNIV ZHEJIANG POLYTECHNIC (CN) | 2005-07-27 | — | — | CN | disclosed |
| WO-1994014784-A1 | NEW THIAZOLIDINONE DERIVATIVES AND A PROCESS FOR THE PREPARATION THEREOF | Richter Gedeon Vegyészeti Gyár Rt. (HU) | 1994-07-07 | — | — | WO | disclosed |
| WO-1994014784-A1 | NEW THIAZOLIDINONE DERIVATIVES AND A PROCESS FOR THE PREPARATION THEREOF | Richter Gedeon Vegyészeti Gyár Rt. (HU) | 1994-07-07 | — | — | WO | disclosed |
| EP-0320910-B1 | 2-Thiazolidinone derivatives, pharmaceutical compositions containing them, process for preparing same, and use | RICHTER GEDEON VEGYESZET (HU) | 1993-12-08 | — | — | EP | disclosed |
| US-4937252-A | 2-thiazolidinone derivatives, pharmaceutical compositions containing them and process for preparing same | RICHTER GEDEON VEGYESZETI GYAR RT. (HU) | 1990-06-26 | — | — | US | disclosed |
| JP-H02279-A | 2-THIAZOLIDINONE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEN AND THEIR PREPARATION | RICHTER GEDEON V G RT | 1990-01-05 | — | — | JP | disclosed |
| EP-0320910-A1 | 2-Thiazolidinone derivatives, pharmaceutical compositions containing them, process for preparing same, and use | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1989-06-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090216024-A1 | Processes for making pioglitazone and compounds of the processes | PDK4, PDK2, DPP4 | MAPK1 3882/4885GSK3A 163/4885GSK3B 130/4885 |
| US-20130165446-A1 | BENZO-OR PYRIDO-IMIDAZOLE DERIVATIVE | PPARG, PPARA, PPARD | MAPK1 1532/4885GSK3A 4410/4885GSK3B 4112/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.