Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11257484 | 0.89 | ALDH1A1 (0.45) | SMN1; SMN2LMNAHTTL3MBTL1ALDH1A1 | |
| SCHEMBL11264404 | 0.86 | ALDH1A1 (0.45) | SMN1; SMN2LMNAHTTL3MBTL1ALDH1A1 | |
| SCHEMBL11264969 | 0.81 | ALDH1A1 (0.48) | SMN1; SMN2LMNAHTTL3MBTL1ALDH1A1 | |
| SCHEMBL11253650 | 0.80 | CACNA1F (0.45) | SMN1; SMN2LMNAHTTL3MBTL1ALDH1A1 | |
| SCHEMBL11270945 | 0.80 | LMNA (0.48) | LMNAHTTL3MBTL1ALDH1A1CYP3A4 | |
| SCHEMBL11269214 | 0.78 | LMNA (0.43) | LMNAHTTL3MBTL1ALDH1A1CYP3A4 | |
| SCHEMBL11266663 | 0.78 | MAPT (0.44) | SMN1; SMN2LMNAHTTL3MBTL1ALDH1A1 | |
| SCHEMBL13916496 | 0.77 | CYP2C19 (0.52) | SMN1; SMN2LMNAHTTL3MBTL1ALDH1A1 | |
| SCHEMBL11255332 | 0.76 | L3MBTL1 (0.42) | SMN1; SMN2LMNAHTTL3MBTL1ALDH1A1 | |
| SCHEMBL11266095 | 0.75 | LMNA (0.40) | SMN1; SMN2LMNAHTTL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4360520-A | 1,4-Dihydropyridazine compounds, and their medicinal use | BAYER AKTIENGESELLSCHAFT (DE) | 1982-11-23 | — | — | US | disclosed |