Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.60 |
| ▸ | THRB | P10828 | 1/20 | 0.60 |
| ▸ | DRD3 | P35462 | 2/20 | 0.60 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.60 |
| ▸ | HTR2A | P28223 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | WNK1 | Q9H4A3 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9513158 | 0.99 | DRD2 (0.59) | DRD2THRBDRD3KCNA5HTR2A | |
| SCHEMBL9513026 | 0.90 | WNK1 (0.64) | DRD2THRBDRD3KCNA5ALDH1A1 | |
| SCHEMBL9514261 | 0.89 | DRD2 (0.76) | DRD2THRBDRD3KCNA5HTR2A | |
| Hydrochloric Acid SCHEMBL9513192 | 0.89 | WNK1 (0.63) | DRD2THRBDRD3KCNA5ALDH1A1 | |
| SCHEMBL9513265 | 0.88 | THRB (0.58) | DRD2THRBDRD3KCNA5HTR2A | |
| Hydrochloric Acid SCHEMBL9514254 | 0.87 | THRB (0.57) | DRD2THRBDRD3KCNA5HTR2A | |
| SCHEMBL9515612 | 0.85 | THRB (0.68) | THRBDRD3KCNA5HTR2AALDH1A1 | |
| SCHEMBL9513235 | 0.84 | KMT2A (0.67) | DRD2THRBDRD3KCNA5ALDH1A1 | |
| Hydrochloric Acid SCHEMBL9516717 | 0.84 | THRB (0.67) | THRBDRD3KCNA5HTR2AALDH1A1 | |
| SCHEMBL9513241 | 0.83 | THRB (0.82) | DRD2THRBDRD3KCNA5HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0250361-B1 | Disubstituted piperazines | CIBA GEIGY AG (CH) | 1993-12-08 | — | — | EP | claimed |
| US-4804661-A | ANALGESICS | CIBA-GEIGY CORPORATION (US) | 1989-02-14 | — | — | US | claimed |
| EP-0250361-A2 | Disubstituted piperazines | CIBA-GEIGY AG (CH) | 1987-12-23 | — | — | EP | claimed |
| EP-0250361-B1 | Disubstituted piperazines | CIBA GEIGY AG (CH) | 1993-12-08 | — | — | EP | disclosed |
| US-4804661-A | ANALGESICS | CIBA-GEIGY CORPORATION (US) | 1989-02-14 | — | — | US | disclosed |
| EP-0250361-A2 | Disubstituted piperazines | CIBA-GEIGY AG (CH) | 1987-12-23 | — | — | EP | disclosed |