Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.76 |
| ▸ | DRD3 | P35462 | 6/20 | 0.74 |
| ▸ | KCNA5 | P22460 | 3/20 | 0.74 |
| ▸ | THRB | P10828 | 1/20 | 0.68 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.61 |
| ▸ | LSS | P48449 | 1/20 | 0.58 |
| ▸ | HTR2A | P28223 | 1/20 | 0.58 |
| ▸ | MGLL | Q99685 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9513241 | 0.90 | THRB (0.82) | DRD2DRD3KCNA5THRBPOLB | |
| SCHEMBL9512958 | 0.89 | DRD2 (0.60) | DRD2DRD3KCNA5THRBSIGMAR1 | |
| Hydrochloric Acid SCHEMBL9513158 | 0.88 | DRD2 (0.59) | DRD2DRD3KCNA5THRBSIGMAR1 | |
| SCHEMBL17444537 | 0.88 | DRD2 (0.76) | DRD2DRD3KCNA5THRBSIGMAR1 | |
| SCHEMBL25284686 | 0.88 | DRD2 (0.75) | DRD2DRD3KCNA5POLBSIGMAR1 | |
| SCHEMBL9513026 | 0.86 | WNK1 (0.64) | DRD2DRD3KCNA5THRBPOLB | |
| SCHEMBL19479125 | 0.86 | DRD2 (1.00) | DRD2DRD3KCNA5SIGMAR1HTR2A | |
| SCHEMBL10898714 | 0.86 | THRB (0.73) | DRD2DRD3KCNA5THRBPOLB | |
| SCHEMBL9512997 | 0.86 | THRB (0.73) | DRD2DRD3KCNA5THRBPOLB | |
| Hydrochloric Acid SCHEMBL9513192 | 0.85 | WNK1 (0.63) | DRD2DRD3KCNA5THRBPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0250361-B1 | Disubstituted piperazines | CIBA GEIGY AG (CH) | 1993-12-08 | — | — | EP | claimed |
| EP-0250361-A2 | Disubstituted piperazines | CIBA-GEIGY AG (CH) | 1987-12-23 | — | — | EP | claimed |
| EP-0250361-B1 | Disubstituted piperazines | CIBA GEIGY AG (CH) | 1993-12-08 | — | — | EP | disclosed |
| US-4804661-A | ANALGESICS | CIBA-GEIGY CORPORATION (US) | 1989-02-14 | — | — | US | disclosed |
| EP-0250361-A2 | Disubstituted piperazines | CIBA-GEIGY AG (CH) | 1987-12-23 | — | — | EP | disclosed |