Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.60 |
| ▸ | THRB | P10828 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | CCR5 | P51681 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9512919 | 0.99 | HTR2A (0.58) | HTR2ATHRBLMNACCR5KMT2A | |
| SCHEMBL9513010 | 0.87 | THRB (0.60) | HTR2ATHRBLMNAKMT2AMEN1 | |
| SCHEMBL9513122 | 0.86 | POLB (0.58) | HTR2ATHRBLMNAKMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL9513193 | 0.86 | THRB (0.58) | HTR2ATHRBLMNAKMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL9516762 | 0.85 | POLB (0.57) | HTR2ATHRBLMNAKMT2AMEN1 | |
| SCHEMBL9513007 | 0.84 | POLB (0.62) | HTR2ATHRBLMNAKMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL9516815 | 0.83 | POLB (0.61) | HTR2ATHRBLMNAKMT2AMEN1 | |
| SCHEMBL9513241 | 0.81 | THRB (0.82) | HTR2ATHRBLMNAKMT2AMEN1 | |
| SCHEMBL9512997 | 0.81 | THRB (0.73) | HTR2ATHRBLMNAKMT2AMEN1 | |
| SCHEMBL9514633 | 0.80 | LMNA (0.80) | HTR2ATHRBLMNAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0250361-B1 | Disubstituted piperazines | CIBA GEIGY AG (CH) | 1993-12-08 | — | — | EP | claimed |
| EP-0250361-A2 | Disubstituted piperazines | CIBA-GEIGY AG (CH) | 1987-12-23 | — | — | EP | claimed |