Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.61 |
| ▸ | HTR2A | P28223 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9516815 | 0.99 | POLB (0.61) | POLBGAAKDM4EALDH1A1HTR2A | |
| SCHEMBL9514318 | 0.87 | POLB (0.82) | POLBGAAKDM4EALDH1A1HTR2A | |
| SCHEMBL9513046 | 0.84 | HTR2A (0.60) | POLBGAAKDM4EALDH1A1HTR2A | |
| SCHEMBL9513010 | 0.84 | THRB (0.60) | HTR2ALMNATHRBMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL9512919 | 0.83 | HTR2A (0.58) | POLBGAAKDM4EALDH1A1HTR2A | |
| Hydrochloric Acid SCHEMBL9513193 | 0.83 | THRB (0.58) | HTR2ALMNATHRBMEN1KMT2A | |
| SCHEMBL9513235 | 0.81 | KMT2A (0.67) | POLBGAAKDM4EALDH1A1MAPK1 | |
| SCHEMBL9513026 | 0.81 | WNK1 (0.64) | POLBKDM4EALDH1A1LMNATHRB | |
| Hydrochloric Acid SCHEMBL9513192 | 0.80 | WNK1 (0.63) | POLBKDM4EALDH1A1LMNATHRB | |
| SCHEMBL9514261 | 0.80 | DRD2 (0.76) | POLBHTR2ATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0250361-B1 | Disubstituted piperazines | CIBA GEIGY AG (CH) | 1993-12-08 | — | — | EP | claimed |
| EP-0250361-A2 | Disubstituted piperazines | CIBA-GEIGY AG (CH) | 1987-12-23 | — | — | EP | claimed |