SCHEMBL951367

SCHEMBL951367

O=C(O)c1cc(Cl)cn1-c1ncccc1Cl

nearest known ligand 0.40

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
TRPA1 O75762 2/20 0.40
MALT1 Q9UDY8 4/20 0.40
LMNA P02545 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
AVPR1A P37288 2/20 0.37
MYC P01106 1/20 0.37
RORC P51449 1/20 0.37
PKM P14618 1/20 0.37
TRPV1 Q8NER1 1/20 0.36
RBP4 P02753 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL950371 0.87 MAPK1 (0.40) TRPA1MALT1SMN1; SMN2AVPR1APKM
SCHEMBL951079 0.86 MALT1 (0.38) TRPA1MALT1LMNASMN1; SMN2MYC
SCHEMBL951639 0.86 MALT1 (0.38) TRPA1MALT1LMNASMN1; SMN2MYC
SCHEMBL951402 0.79 POLB (0.47) TRPA1MALT1LMNASMN1; SMN2MYC
SCHEMBL12528652 0.75 TRPV1 (0.42) TRPA1MALT1LMNASMN1; SMN2AVPR1A
SCHEMBL951737 0.75 MYC (0.41) TRPA1MALT1LMNASMN1; SMN2AVPR1A
SCHEMBL950203 0.75 TRPA1 (0.36) TRPA1MALT1SMN1; SMN2AVPR1ATRPV1
SCHEMBL384656 0.73 KMT2A (0.43) MALT1LMNASMN1; SMN2
SCHEMBL958268 0.73 MALT1 (0.40) TRPA1MALT1LMNASMN1; SMN2MYC
SCHEMBL29558300 0.73 MALT1 (0.40) TRPA1MALT1LMNASMN1; SMN2MYC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101287721-B Hydrazide compound and pesticidal use of the same SUMITOMO CO LTD 2013-03-27 CN disclosed
US-7968573-B2 Hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-06-28 US disclosed
EP-1937664-B1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL CO (JP) 2011-06-15 EP disclosed
EP-1937664-B1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL CO (JP) 2011-06-15 EP disclosed
US-20110071291-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME IKEGAMI HIROSHI 2011-03-24 US disclosed
US-7867949-B2 Hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-11 US disclosed
EP-2251336-A1 Hydrazide compounds as intermediates of pesticides Sumitomo Chemical Company, Limited (JP) 2010-11-17 EP disclosed
EP-2251336-A1 Hydrazide compounds as intermediates of pesticides Sumitomo Chemical Company, Limited (JP) 2010-11-17 EP disclosed
US-20090181956-A1 Hydrazide Compound and Pesticidal Use of the Same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-07-16 US disclosed
CN-101287721-A Hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL CO (JP) 2008-10-15 CN disclosed
EP-1937664-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME Sumitomo Chemical Company, Limited (JP) 2008-07-02 EP disclosed
WO-2007043677-A9 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL CO (JP) 2007-06-07 WO disclosed
WO-2007043677-A9 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL CO (JP) 2007-06-07 WO disclosed
WO-2007043677-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2007-04-19 WO disclosed
WO-2007043677-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2007-04-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110071291-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME ACHE, H1-2, H1-0 TRPA1 437/4885MALT1 4856/4885LMNA 2981/4885
US-20090181956-A1 Hydrazide Compound and Pesticidal Use of the Same ACHE, DDT, CAT TRPA1 359/4885MALT1 4865/4885LMNA 4343/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.