SCHEMBL12528652

SCHEMBL12528652

Cc1cc(Cl)cn1-c1ncccc1Cl

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRPV1 Q8NER1 3/20 0.42
HSD11B1 P28845 2/20 0.39
MALT1 Q9UDY8 2/20 0.36
LMNA P02545 2/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
TRPA1 O75762 2/20 0.35
CYP17A1 P05093 1/20 0.35
CYP1A2 P05177 1/20 0.35
PHGDH O43175 1/20 0.35
AVPR1A P37288 1/20 0.35
TNKS O95271 1/20 0.35
CCR1 P32246 1/20 0.34
CCR8 P51685 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
KDM4E B2RXH2 1/20 0.34
BRD4 O60885 1/20 0.34
HSP90AA1 P07900 1/20 0.34
MAPT P10636 1/20 0.34
METAP2 P50579 1/20 0.34
METAP1 P53582 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12528693 0.84 TRPV1 (0.40) TRPV1HSD11B1MALT1LMNASMN1; SMN2
SCHEMBL12528531 0.84 TRPV1 (0.40) TRPV1HSD11B1MALT1SMN1; SMN2CYP17A1
SCHEMBL950203 0.76 TRPA1 (0.36) TRPV1HSD11B1MALT1SMN1; SMN2TRPA1
SCHEMBL12528529 0.76 TRPV1 (0.41) TRPV1HSD11B1MALT1CYP17A1CYP1A2
SCHEMBL951367 0.75 TRPA1 (0.40) TRPV1MALT1LMNASMN1; SMN2TRPA1
SCHEMBL950371 0.74 MAPK1 (0.40) TRPV1MALT1SMN1; SMN2TRPA1AVPR1A
SCHEMBL8498623 0.72 CYP3A4 (0.50) TRPV1HSD11B1CYP17A1CYP1A2
SCHEMBL12528624 0.71 TRPV1 (0.40) TRPV1HSD11B1MALT1TRPA1CYP17A1
SCHEMBL13105266 0.70 CYP17A1 (0.40) TRPV1HSD11B1MALT1LMNACYP17A1
SCHEMBL12528188 0.70 ALDH1A1 (0.51) LMNAL3MBTL1KDM4EMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7968573-B2 Hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-06-28 US disclosed
US-20110071291-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME IKEGAMI HIROSHI 2011-03-24 US disclosed
US-7867949-B2 Hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-11 US disclosed
US-20090181956-A1 Hydrazide Compound and Pesticidal Use of the Same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-07-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110071291-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME ACHE, H1-2, H1-0 TRPV1 1056/4885HSD11B1 1797/4885MALT1 4856/4885
US-20090181956-A1 Hydrazide Compound and Pesticidal Use of the Same ACHE, DDT, CAT TRPV1 687/4885HSD11B1 651/4885MALT1 4865/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.