Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | HPGDS | O60760 | 4/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | PRCP | P42785 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.44 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.44 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.44 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.44 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14983903 | 0.85 | KMT2A (0.61) | LMNAHPGDSTSHRKMT2AMEN1 | |
| SCHEMBL14646356 | 0.85 | LMNA (0.51) | LMNAHPGDSTSHRKMT2AMEN1 | |
| SCHEMBL12310855 | 0.84 | PRCP (0.56) | LMNAPRCPKMT2AMEN1ALDH1A1 | |
| SCHEMBL4426855 | 0.81 | LMNA (0.49) | LMNAHPGDSTSHRKMT2AMEN1 | |
| SCHEMBL12863553 | 0.79 | RIPK1 (0.69) | LMNAHPGDSTSHRKMT2AMEN1 | |
| SCHEMBL8358267 | 0.77 | HPGDS (0.49) | LMNAHPGDSTSHRKMT2AMEN1 | |
| SCHEMBL7317251 | 0.75 | LMNA (0.50) | LMNAHPGDSTSHRKMT2AMEN1 | |
| SCHEMBL7317247 | 0.75 | LMNA (0.50) | LMNAHPGDSTSHRKMT2AMEN1 | |
| SCHEMBL425361 | 0.74 | ALDH1A1 (0.58) | LMNAHPGDSTSHRKMT2AMEN1 | |
| SCHEMBL1386996 | 0.74 | LMNA (0.79) | LMNAHPGDSTSHRKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0333938-B1 | 2-HYDROXY-3-ARYLOXY-PROPYLAMINE DERIVATIVES HAVING CARDIOVASCULAR ACTIVITY | ZAMBON GROUP S.p.A. (IT) | 1993-04-14 | — | — | EP | disclosed |
| US-5047425-A | Amine derivatives having cardiovascular activity | SIMES SOCIETA ITALIANA MEDICINALI & SINTETICI SPA (IT) | 1991-09-10 | — | — | US | disclosed |
| EP-0333938-A1 | 2-Hydroxy-3-aryloxy-propylamine derivatives having cardiovascular activity | ZAMBON GROUP S.p.A. (IT) | 1989-09-27 | — | — | EP | disclosed |