Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.53 |
| ▸ | DRD2 | P14416 | 3/20 | 0.53 |
| ▸ | CA1 | P00915 | 10/20 | 0.52 |
| ▸ | CA2 | P00918 | 10/20 | 0.52 |
| ▸ | CA9 | Q16790 | 10/20 | 0.52 |
| ▸ | CA7 | P43166 | 8/20 | 0.52 |
| ▸ | CA12 | O43570 | 3/20 | 0.52 |
| ▸ | CA4 | P22748 | 3/20 | 0.52 |
| ▸ | CA5A | P35218 | 2/20 | 0.52 |
| ▸ | CA13 | Q8N1Q1 | 2/20 | 0.52 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.52 |
| ▸ | DRD4 | P21917 | 1/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | CLEC4M | Q9H2X3 | 1/20 | 0.48 |
| ▸ | CD209 | Q9NNX6 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10680303 | 0.83 | CA2 (0.66) | CA1CA2CA9CA7CA12 | |
| SCHEMBL7402290 | 0.82 | HTR1A (0.55) | HTR1ADRD2DRD4SLC6A4SMN1; SMN2 | |
| SCHEMBL9514747 | 0.79 | HTR1A (0.58) | HTR1ADRD2DRD4SLC6A4LMNA | |
| SCHEMBL27928479 | 0.78 | HRH3 (0.60) | CA1CA2CA9CA7CA12 | |
| SCHEMBL7401572 | 0.78 | SMN1; SMN2 (0.60) | HTR1ADRD2CA1CA2CA9 | |
| SCHEMBL9513747 | 0.77 | KMT2A (0.53) | HTR1ACA1CA2CA9CA7 | |
| SCHEMBL9513528 | 0.77 | CA1 (0.54) | CA1CA2CA9CA7CA12 | |
| SCHEMBL9514721 | 0.75 | CA2 (0.61) | CA1CA2CA9CA7CA12 | |
| SCHEMBL7399968 | 0.74 | HTR1A (0.48) | HTR1ADRD2DRD4SLC6A4LMNA | |
| SCHEMBL9516047 | 0.73 | CA1 (0.58) | CA1CA2CA9CA7CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233051-B1 | ANTIARRHYTHMIC AGENTS | Pfizer Limited (GB) | 1993-09-15 | — | — | EP | disclosed |
| US-4806536-A | Piperazinyl-substituted pyridine and imidazole anti-arrhythmic agents | PFIZER, INC. (US) | 1989-02-21 | — | — | US | disclosed |
| EP-0233051-A2 | Antiarrhythmic Agents | Pfizer Limited (GB) | 1987-08-19 | — | — | EP | disclosed |