Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 12/20 | 0.58 |
| ▸ | DRD2 | P14416 | 12/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 2/20 | 0.46 |
| ▸ | HTR2C | P28335 | 2/20 | 0.46 |
| ▸ | HTR2B | P41595 | 2/20 | 0.46 |
| ▸ | HTR1D | P28221 | 1/20 | 0.45 |
| ▸ | HTR1B | P28222 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10359567 | 0.91 | LMNA (0.55) | HTR1ADRD2LMNASMN1; SMN2GRIN1 | |
| Hydrochloric Acid SCHEMBL10359568 | 0.90 | LMNA (0.54) | HTR1ADRD2LMNASMN1; SMN2GRIN1 | |
| Hydrochloric Acid SCHEMBL10560001 | 0.89 | LMNA (0.53) | HTR1ADRD2LMNASMN1; SMN2GRIN1 | |
| Hydrochloric Acid SCHEMBL10560007 | 0.89 | LMNA (0.53) | HTR1ADRD2LMNASMN1; SMN2GRIN1 | |
| SCHEMBL9513748 | 0.88 | JAK2 (0.51) | HTR1ADRD2LMNASMN1; SMN2GRIN1 | |
| SCHEMBL10680323 | 0.84 | JAK2 (0.50) | LMNASMN1; SMN2GRIN1GRIN2BKCNH2 | |
| SCHEMBL10577329 | 0.81 | KMT2A (0.53) | HTR1A | |
| SCHEMBL9224604 | 0.81 | SPHK1 (0.51) | HTR1ALMNAKCNH2 | |
| SCHEMBL7854117 | 0.80 | LTA4H (0.56) | LMNASMN1; SMN2KCNH2 | |
| SCHEMBL10562489 | 0.79 | GRIN1 (0.50) | HTR1ADRD2LMNASMN1; SMN2GRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233051-B1 | ANTIARRHYTHMIC AGENTS | Pfizer Limited (GB) | 1993-09-15 | — | — | EP | disclosed |
| US-4806536-A | Piperazinyl-substituted pyridine and imidazole anti-arrhythmic agents | PFIZER, INC. (US) | 1989-02-21 | — | — | US | disclosed |
| EP-0238576-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS. | MERCK PATENT GMBH (DE) | 1987-09-30 | — | — | EP | disclosed |
| EP-0233051-A2 | Antiarrhythmic Agents | Pfizer Limited (GB) | 1987-08-19 | — | — | EP | disclosed |
| WO-1987001701-A2 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1987-03-26 | — | — | WO | disclosed |