Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.51 |
| ▸ | ADRB2 | P07550 | 6/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 6/20 | 0.48 |
| ▸ | ADRB3 | P13945 | 6/20 | 0.48 |
| ▸ | HTR1A | P08908 | 7/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6375438 | 0.89 | SPHK1 (0.60) | SPHK1ADRB2ADRB1ADRB3KCNH2 | |
| SCHEMBL9225437 | 0.81 | LMNA (0.56) | ADRB2ADRB1ADRB3HTR1AKCNH2 | |
| SCHEMBL9514747 | 0.81 | HTR1A (0.58) | HTR1AKCNH2LMNA | |
| SCHEMBL10561148 | 0.80 | ADRB2 (0.62) | SPHK1ADRB2ADRB1ADRB3KCNH2 | |
| SCHEMBL10680323 | 0.79 | JAK2 (0.50) | ADRB2ADRB1ADRB3KCNH2LMNA | |
| SCHEMBL10577329 | 0.79 | KMT2A (0.53) | HTR1AMEN1KMT2A | |
| SCHEMBL10578945 | 0.79 | SPHK1 (0.62) | SPHK1ADRB2ADRB1ADRB3HTR1A | |
| SCHEMBL9513748 | 0.78 | JAK2 (0.51) | ADRB2ADRB1ADRB3HTR1AKCNH2 | |
| SCHEMBL10580782 | 0.77 | SPHK1 (0.57) | SPHK1ADRB2ADRB1ADRB3HTR1A | |
| SCHEMBL9513791 | 0.77 | ADRB2 (0.51) | SPHK1ADRB2ADRB1ADRB3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5405997-A | Stable against rapid metabolism | THE UPJOHN COMPANY (US) | 1995-04-11 | — | — | US | disclosed |
| EP-0484378-B1 | ANTIARRHYTHMIC TERTIARY AMINE-ALKENYL-PHENYL-ALKANESULFONAMIDES | UPJOHN CO (US) | 1994-09-14 | — | — | EP | disclosed |
| EP-0484378-A1 | ANTIARRHYTHMIC TERTIARY AMINE-ALKENYL-PHENYL-ALKANESULFONAMIDES. | UPJOHN CO (US) | 1992-05-13 | — | — | EP | disclosed |
| WO-1991001299-A1 | ANTIARRHYTHMIC TERTIARY AMINE-ALKENYL-PHENYL-ALKANESULFONAMIDES | THE UPJOHN COMPANY (US) | 1991-02-07 | — | — | WO | disclosed |
| US-4806536-A | Piperazinyl-substituted pyridine and imidazole anti-arrhythmic agents | PFIZER, INC. (US) | 1989-02-21 | — | — | US | disclosed |
| EP-0233051-A2 | Antiarrhythmic Agents | Pfizer Limited (GB) | 1987-08-19 | — | — | EP | disclosed |