Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 5/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | JAK3 | P52333 | 3/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.46 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.46 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9514747 | 0.88 | HTR1A (0.58) | KCNH2SMN1; SMN2LMNAGRIN1GRIN2B | |
| SCHEMBL10680323 | 0.86 | JAK2 (0.50) | JAK2JAK3KCNH2SMN1; SMN2ADRB2 | |
| SCHEMBL8781020 | 0.84 | DRD4 (0.60) | POLBADRB2ADRB1ADRB3ALDH1A1 | |
| SCHEMBL9513736 | 0.81 | POLB (0.49) | POLBKCNH2SMN1; SMN2MEN1KMT2A | |
| SCHEMBL9224925 | 0.80 | ADRB2 (0.42) | JAK2POLBKCNH2SMN1; SMN2MEN1 | |
| SCHEMBL6375438 | 0.80 | SPHK1 (0.60) | KCNH2MEN1KMT2AADRB2ADRB1 | |
| SCHEMBL9224917 | 0.80 | ADRB2 (0.42) | JAK2POLBKCNH2SMN1; SMN2MEN1 | |
| SCHEMBL10577329 | 0.79 | KMT2A (0.53) | MEN1KMT2AHTR1A | |
| SCHEMBL9224604 | 0.78 | SPHK1 (0.51) | KCNH2MEN1KMT2AADRB2ADRB1 | |
| SCHEMBL23964263 | 0.78 | DRD2 (0.47) | KCNH2SMN1; SMN2LMNACYP2D6GRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233051-B1 | ANTIARRHYTHMIC AGENTS | Pfizer Limited (GB) | 1993-09-15 | — | — | EP | disclosed |
| US-4806536-A | Piperazinyl-substituted pyridine and imidazole anti-arrhythmic agents | PFIZER, INC. (US) | 1989-02-21 | — | — | US | disclosed |
| EP-0233051-A2 | Antiarrhythmic Agents | Pfizer Limited (GB) | 1987-08-19 | — | — | EP | disclosed |