Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 2/20 | 0.65 |
| ▸ | LSS | P48449 | 1/20 | 0.60 |
| ▸ | HSD11B1 | P28845 | 6/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | PKM | P14618 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | ABL1 | P00519 | 1/20 | 0.52 |
| ▸ | BCR | P11274 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9517357 | 0.86 | LSS (0.55) | GBA1LSSHSD11B1MEN1KMT2A | |
| SCHEMBL6975619 | 0.82 | LSS (0.62) | GBA1LSSHSD11B1PKMALDH1A1 | |
| SCHEMBL6977387 | 0.82 | LSS (0.76) | GBA1LSSMEN1KMT2AGAA | |
| SCHEMBL9513912 | 0.81 | LMNA (0.53) | GBA1LSSALDH1A1KDM4EMAPT | |
| SCHEMBL8466387 | 0.81 | LSS (0.48) | GBA1LSSALDH1A1KDM4EMAPT | |
| SCHEMBL5862112 | 0.80 | KDM4E (0.76) | HSD11B1MEN1KMT2AGAASMN1; SMN2 | |
| SCHEMBL6978604 | 0.79 | LSS (0.71) | GBA1LSSMEN1KMT2AGAA | |
| SCHEMBL7588700 | 0.78 | SORD (0.68) | GBA1LSSMEN1KMT2AGAA | |
| SCHEMBL8467030 | 0.78 | LSS (0.46) | GBA1LSSMEN1KMT2AALDH1A1 | |
| SCHEMBL7654703 | 0.78 | HTR7 (0.56) | GBA1LSSHSD11B1PKMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0384370-B1 | Substituted pyrimidine derivatives, process for their preparation, and their use as tool | HOECHST AG (DE) | 1993-11-03 | — | — | EP | disclosed |
| US-5138058-A | Diabetic screening | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-08-11 | — | — | US | disclosed |
| EP-0384370-A1 | Substituted pyrimidine derivatives, process for their preparation, and their use as tool | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-08-29 | — | — | EP | disclosed |