Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | LSS | P48449 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | SORD | Q00796 | 4/20 | 0.42 |
| ▸ | COMT | P21964 | 1/20 | 0.41 |
| ▸ | GBA1 | P04062 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10441542 | 0.81 | ALDH1A1 (0.49) | ALDH1A1L3MBTL1SMN1; SMN2RAB9AHTT | |
| SCHEMBL8466387 | 0.76 | LSS (0.48) | ALDH1A1LSSLMNAMAPTSORD | |
| SCHEMBL9513912 | 0.76 | LMNA (0.53) | ALDH1A1RAB9ALSSLMNAMAPT | |
| SCHEMBL9514839 | 0.76 | GBA1 (0.65) | ALDH1A1SMN1; SMN2LSSHTTMEN1 | |
| SCHEMBL11115556 | 0.75 | ALDH1A1 (0.51) | ALDH1A1L3MBTL1SMN1; SMN2RAB9AHTT | |
| SCHEMBL9267796 | 0.74 | ALDH1A1 (0.71) | ALDH1A1L3MBTL1SMN1; SMN2RAB9AMEN1 | |
| SCHEMBL7588700 | 0.73 | SORD (0.68) | ALDH1A1L3MBTL1SMN1; SMN2LSSHTT | |
| SCHEMBL8467030 | 0.73 | LSS (0.46) | ALDH1A1LSSMEN1MAPTKMT2A | |
| SCHEMBL9517357 | 0.71 | LSS (0.55) | ALDH1A1SMN1; SMN2LSSHTTMEN1 | |
| SCHEMBL6975619 | 0.70 | LSS (0.62) | ALDH1A1L3MBTL1RAB9ALSSHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0384370-B1 | Substituted pyrimidine derivatives, process for their preparation, and their use as tool | HOECHST AG (DE) | 1993-11-03 | — | — | EP | disclosed |
| EP-0384370-A1 | Substituted pyrimidine derivatives, process for their preparation, and their use as tool | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-08-29 | — | — | EP | disclosed |