Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 5/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4128527 | 0.91 | LMNA (0.50) | CHRM3CHRM2CHRM4CHRM1LMNA | |
| Urea SCHEMBL2447795 | 0.78 | MAPK1 (0.48) | CHRM3CHRM2CHRM4CHRM1MAPK1 | |
| SCHEMBL31008717 | 0.76 | SMN1; SMN2 (0.36) | CHRM1LMNACYP2C9SMN1; SMN2BCHE | |
| SCHEMBL7397644 | 0.75 | ALDH1A1 (0.49) | ALDH1A1KMT2ACYP2D6 | |
| SCHEMBL7397643 | 0.75 | ALDH1A1 (0.49) | ALDH1A1KMT2ACYP2D6 | |
| SCHEMBL3438642 | 0.74 | — | — | |
| SCHEMBL21145976 | 0.73 | SMN1; SMN2 (0.37) | CHRM3CHRM1LMNACYP2C9SMN1; SMN2 | |
| SCHEMBL6648506 | 0.71 | LMNA (0.52) | CHRM3CHRM2CHRM4CHRM1LMNA | |
| SCHEMBL8947045 | 0.71 | LMNA (0.52) | CHRM3CHRM2CHRM4CHRM1LMNA | |
| SCHEMBL11388564 | 0.71 | LMNA (0.52) | CHRM3CHRM2CHRM4CHRM1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0422154-B1 | THERAPEUTIC USE OF 5-HT3 RECEPTOR ANTAGONISTS | SANDOZ AG (AT) | 1993-12-01 | — | — | EP | claimed |
| EP-0339950-A2 | Dibenzofurancarboxamides, their use as pharmaceutical agents, a composition containing the same, and a process for the preparation thereof | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1989-11-02 | — | — | EP | disclosed |