Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 2/20 | 0.43 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.35 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 2/20 | 0.34 |
| ▸ | PTGES | O14684 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9515238 | 1.00 | TBXAS1 (0.43) | TBXAS1GRIK1EPHX2S1PR2CYP3A4 | |
| SCHEMBL12499092 | 0.84 | TBXAS1 (0.36) | TBXAS1EPHX2CYP2C9ALDH1A1MAPK1 | |
| SCHEMBL12499098 | 0.84 | TBXAS1 (0.36) | TBXAS1EPHX2CYP2C9ALDH1A1MAPK1 | |
| SCHEMBL17053149 | 0.81 | TBXAS1 (0.43) | TBXAS1EPHX2CYP3A4CYP2C9PPARG | |
| SCHEMBL2392804 | 0.79 | TTR (0.41) | TBXAS1GRIK1EPHX2CYP3A4CYP2C9 | |
| SCHEMBL1914012 | 0.77 | TBXAS1 (0.47) | TBXAS1GRIK1EPHX2CYP3A4CYP2C9 | |
| SCHEMBL12499649 | 0.77 | TBXAS1 (0.50) | TBXAS1GRIK1EPHX2CYP3A4CYP2C9 | |
| SCHEMBL12499645 | 0.77 | TBXAS1 (0.50) | TBXAS1GRIK1EPHX2CYP3A4CYP2C9 | |
| SCHEMBL2391722 | 0.76 | ALDH1A1 (0.44) | TBXAS1CYP3A4PPARGESR1PSEN1 | |
| SCHEMBL5991566 | 0.76 | TBXAS1 (0.46) | TBXAS1GRIK1EPHX2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765054-B2 | Histone deacetylase inhibitors and compositions and methods of use thereof | CHDI FOUNDATION, INC. (US) | 2017-09-19 | — | — | US | disclosed |
| US-20140163009-A1 | HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF | CHDI Foundation (US) | 2014-06-12 | — | — | US | disclosed |
| EP-2667709-A1 | HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF | CHDI Foundation, Inc. (US) | 2013-12-04 | — | — | EP | disclosed |
| WO-2012103008-A1 | HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF | CHDI FOUNDATION, INC. (US) | 2012-08-02 | — | — | WO | disclosed |
| EP-0369762-B1 | Pesticides | ROUSSEL UCLAF (FR) | 1993-12-29 | — | — | EP | disclosed |
| US-5202356-A | Insecticides, miticides | THE WELLCOME FOUNDATION LIMITED (GB) | 1993-04-13 | — | — | US | disclosed |
| EP-0369762-A1 | Pesticides | ROUSSEL-UCLAF (FR) | 1990-05-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140163009-A1 | HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF | HDAC1, HDAC7, HDAC5 | TBXAS1 3168/4885GRIK1 963/4885EPHX2 1683/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.