Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 8/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 6/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.36 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.36 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9517222 | 0.90 | TRPM8 (0.38) | TRPM8HIF1AEPAS1SCN9ASCN5A | |
| SCHEMBL9517908 | 0.89 | CXCR1 (0.39) | P4HTMEPHX2HDAC3HDAC1HDAC2 | |
| SCHEMBL9516087 | 0.89 | BCL2L1 (0.38) | TRPM8HIF1AEPAS1SCN9ASCN5A | |
| SCHEMBL9519391 | 0.89 | HDAC6 (0.38) | SCN9ASCN5AKCNH2FAAHHDAC3 | |
| SCHEMBL9517937 | 0.87 | EGFR (0.40) | SCN9ASCN5AP4HTM | |
| SCHEMBL9515768 | 0.87 | HIF1A (0.40) | TRPM8HIF1AEPAS1SCN9AP4HTM | |
| SCHEMBL9515457 | 0.85 | SMN1; SMN2 (0.38) | GAAP4HTM | |
| SCHEMBL9516012 | 0.83 | HSD11B1 (0.39) | TRPM8HIF1AEPAS1SCN9ASCN5A | |
| SCHEMBL9516990 | 0.83 | P4HTM (0.37) | SCN9ASCN5AKCNH2P4HTMHDAC6 | |
| SCHEMBL9516262 | 0.82 | GRM5 (0.40) | P4HTMHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0567997-A1 | 4- or 5-(sulf)imido- and (sulfon)amidopyridines and their pyridine-N-oxides, process for their preparation and their use as pharmaceutical | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-11-03 | — | — | EP | disclosed |