Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.38 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.37 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.37 |
| ▸ | VNN1 | O95497 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9518019 | 0.88 | MEN1 (0.39) | HDAC3HDAC1HDAC2HDAC6HDAC4 | |
| SCHEMBL9517174 | 0.88 | HDAC1 (0.39) | HDAC3HDAC1HDAC2HDAC6TRPM8 | |
| SCHEMBL9516010 | 0.87 | TRPM8 (0.38) | HIF1AEPAS1HDAC3HDAC1HDAC2 | |
| SCHEMBL9517222 | 0.86 | TRPM8 (0.38) | HIF1AEPAS1HDAC3HDAC1HDAC2 | |
| SCHEMBL9516974 | 0.86 | EGFR (0.44) | HDAC3HDAC1HDAC2HDAC6HDAC4 | |
| SCHEMBL9516276 | 0.86 | HIF1A (0.39) | HIF1AEPAS1HDAC3HDAC1HDAC2 | |
| SCHEMBL9516087 | 0.84 | BCL2L1 (0.38) | HIF1AEPAS1TRPM8P4HTMVNN1 | |
| SCHEMBL9515967 | 0.84 | HIF1A (0.38) | HIF1AEPAS1HDAC3HDAC1HDAC2 | |
| SCHEMBL9515748 | 0.82 | P4HTM (0.39) | HDAC6P4HTMMEN1NPC1RAB9A | |
| SCHEMBL9516883 | 0.81 | MMP1 (0.39) | P4HTMKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0567997-A1 | 4- or 5-(sulf)imido- and (sulfon)amidopyridines and their pyridine-N-oxides, process for their preparation and their use as pharmaceutical | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-11-03 | — | — | EP | disclosed |