Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.38 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9516886 | 0.90 | MMP1 (0.40) | MMP1SMN1; SMN2LMNASTAT3GAA | |
| SCHEMBL9517219 | 0.86 | GABRA5 (0.38) | GABRA5MMP1SMN1; SMN2LMNASTAT3 | |
| SCHEMBL9518016 | 0.85 | MEN1 (0.38) | GABRA5GAA | |
| SCHEMBL9515897 | 0.85 | EGFR (0.42) | GABRA5ADRB2ADRB1ADRB3PPARG | |
| SCHEMBL9516300 | 0.83 | GABRA5 (0.48) | GABRA5SMN1; SMN2GAAHPGDALDH1A1 | |
| SCHEMBL9516030 | 0.83 | GABRA5 (0.44) | GABRA5MMP1SMN1; SMN2PPARG | |
| SCHEMBL9515974 | 0.82 | HIF1A (0.39) | — | |
| SCHEMBL9517984 | 0.81 | GABRA5 (0.42) | GABRA5MMP1SMN1; SMN2LMNASTAT3 | |
| SCHEMBL9519314 | 0.81 | EGFR (0.37) | GABRA5ADRB2ADRB1ADRB3PPARG | |
| SCHEMBL9515466 | 0.80 | SMN1; SMN2 (0.38) | GABRA5MMP1SMN1; SMN2LMNASTAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0567997-A1 | 4- or 5-(sulf)imido- and (sulfon)amidopyridines and their pyridine-N-oxides, process for their preparation and their use as pharmaceutical | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-11-03 | — | — | EP | disclosed |