Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9516279 | 0.95 | HIF1A (0.39) | HIF1AEPAS1HDAC3HDAC1HDAC2 | |
| SCHEMBL9518016 | 0.89 | MEN1 (0.38) | HDAC3HDAC1HDAC2HDAC6MEN1 | |
| SCHEMBL9515773 | 0.89 | HSD11B1 (0.43) | HIF1AEPAS1HDAC3HDAC1HDAC2 | |
| SCHEMBL9515431 | 0.89 | PNMT (0.41) | HDAC3HDAC1HDAC2HDAC6CES2 | |
| SCHEMBL9515897 | 0.87 | EGFR (0.42) | HDAC3HDAC1HDAC2HDAC6PPARD | |
| SCHEMBL9519439 | 0.83 | PNMT (0.42) | HDAC3HDAC1HDAC2HDAC6CES2 | |
| SCHEMBL9515637 | 0.83 | EPHX2 (0.38) | HDAC3HDAC1HDAC2HDAC6MEN1 | |
| SCHEMBL9519314 | 0.82 | EGFR (0.37) | HDAC6MEN1NPC1RAB9AKMT2A | |
| SCHEMBL9516131 | 0.82 | GABRA5 (0.40) | — | |
| SCHEMBL9519674 | 0.81 | EGFR (0.43) | HDAC3HDAC1HDAC2HDAC6PPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0567997-A1 | 4- or 5-(sulf)imido- and (sulfon)amidopyridines and their pyridine-N-oxides, process for their preparation and their use as pharmaceutical | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-11-03 | — | — | EP | disclosed |