Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 12/20 | 1.00 |
| ▸ | DAO | P14920 | 2/20 | 0.56 |
| ▸ | NSD2 | O96028 | 1/20 | 0.56 |
| ▸ | BCHE | P06276 | 1/20 | 0.56 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.41 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.41 |
| ▸ | LIG1 | P18858 | 1/20 | 0.40 |
| ▸ | TGM2 | P21980 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | CASP2 | P42575 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | CASP6 | P55212 | 1/20 | 0.36 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ALKBH3 | Q96Q83 | 1/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Isatin SCHEMBL18301370 | 0.87 | CES1 (0.77) | CES1DAONSD2BCHETGM2 | |
| SCHEMBL1248801 | 0.80 | CES1 (1.00) | CES1DAONSD2BCHEDNMT1 | |
| SCHEMBL2892415 | 0.80 | CES1 (0.67) | CES1DAONSD2BCHEDNMT1 | |
| SCHEMBL6315804 | 0.78 | CES1 (0.63) | CES1DAONSD2BCHEDNMT1 | |
| SCHEMBL11029570 | 0.78 | CES1 (0.63) | CES1DAONSD2BCHEDNMT1 | |
| SCHEMBL14358786 | 0.77 | CES1 (0.67) | CES1DAONSD2BCHEDNMT1 | |
| SCHEMBL29689346 | 0.77 | CES1 (0.62) | CES1DAONSD2BCHEDNMT1 | |
| SCHEMBL3080757 | 0.77 | CES1 (0.67) | CES1DAONSD2BCHEDNMT1 | |
| SCHEMBL1092103 | 0.77 | CES1 (0.62) | CES1DAONSD2BCHEDNMT1 | |
| SCHEMBL30441928 | 0.77 | CES1 (0.67) | CES1DAONSD2BCHEDNMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111574426-A | Diamine monomer containing isoindigo structure and black polyimide synthesized from diamine monomer | 湘潭大学 | 2020-08-25 | — | — | CN | claimed |
| US-12180159-B2 | Activators of the unfolded protein response | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2024-12-31 | — | — | US | disclosed |
| CN-113912609-B | Preparation method of natural alkaloid tryptanthrin and derivatives thereof | 江苏大学 | 2024-01-05 | — | — | CN | disclosed |
| US-11584718-B2 | Activators of the unfolded protein response | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2023-02-21 | — | — | US | disclosed |
| US-11174267-B2 | Spiroindolinones and therapeutic uses thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-11-16 | — | — | US | disclosed |
| WO-2021222738-A1 | COMPOUNDS FOR ESTROGEN RECEPTOR POSITIVE CANCERS | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2021-11-04 | — | — | WO | disclosed |
| US-20210340100-A1 | ACTIVATORS OF THE UNFOLDED PROTEIN RESPONSE | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2021-11-04 | — | — | US | disclosed |
| US-20210276951-A1 | ACTIVATORS OF THE UNFOLDED PROTEIN RESPONSE | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2021-09-09 | — | — | US | disclosed |
| US-20210276951-A1 | ACTIVATORS OF THE UNFOLDED PROTEIN RESPONSE | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2021-09-09 | — | — | US | disclosed |
| US-11046647-B2 | Activators of the unfolded protein response | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2021-06-29 | — | — | US | disclosed |
| US-20050288257-A1 | Novel stable compositions of water and oxygen sensitive compounds and their method of preparation | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2005-12-29 | — | — | US | disclosed |
| US-6969729-B2 | Use of isatin derivatives as ion channel activating agents | NEUROSEARCH A/S (DK) | 2005-11-29 | — | — | US | disclosed |
| WO-2005097107-A2 | DIPHENYL - INDOL-2-ON COMPOUNDS AND THEIR USE IN THE TREATMENT OF CANCER | TOPOTARGET A/S (DK) | 2005-10-20 | — | — | WO | disclosed |
| WO-2005097107-A2 | DIPHENYL - INDOL-2-ON COMPOUNDS AND THEIR USE IN THE TREATMENT OF CANCER | TOPOTARGET A/S (DK) | 2005-10-20 | — | — | WO | disclosed |
| EP-1135123-B1 | USE OF ISATIN DERIVATIVES AS ION CHANNEL ACTIVATING AGENTS | NEUROSEARCH AS (DK) | 2004-12-29 | — | — | EP | disclosed |
| US-20030114513-A1 | Use of isatin derivatives as ion channel activating agents | NEUROSEARCH A/S | 2003-06-19 | — | — | US | disclosed |
| US-20020028936-A1 | 1,3-disubstituted indolin-2-ones for neoplasia | OSI PHARMACEUTICALS, INC. | 2002-03-07 | — | — | US | disclosed |
| US-20020016354-A1 | Use of isatin derivatives as ion channel activating agents | NEUROSEARCH A/S (DK) | 2002-02-07 | — | — | US | disclosed |
| EP-1135123-A1 | USE OF ISATIN DERIVATIVES AS ION CHANNEL ACTIVATING AGENTS | NEUROSEARCH A/S (DK) | 2001-09-26 | — | — | EP | disclosed |
| WO-2000033834-A1 | USE OF ISATIN DERIVATIVES AS ION CHANNEL ACTIVATING AGENTS | NEUROSEARCH A/S (DK) | 2000-06-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030114513-A1 | Use of isatin derivatives as ion channel activating agents | KCNN3, KCNJ2, KCND2 | CES1 2434/4885DAO 4805/4885NSD2 2023/4885 |
| US-20050288257-A1 | Novel stable compositions of water and oxygen sensitive compounds and their method of preparation | COXFA4L2, CYP2F1, ABCG2 | CES1 3440/4885DAO 620/4885NSD2 2732/4885 |
| US-11584718-B2 | Activators of the unfolded protein response | HSPA5, DDIT3, XBP1 | CES1 2444/4885DAO 3918/4885NSD2 2905/4885 |
| US-20020028936-A1 | 1,3-disubstituted indolin-2-ones for neoplasia | TP53, MYC, VHL | CES1 2936/4885DAO 3875/4885NSD2 509/4885 |
| US-11046647-B2 | Activators of the unfolded protein response | HSPA5, DDIT3, XBP1 | CES1 2444/4885DAO 3918/4885NSD2 2905/4885 |
| US-20210276951-A1 | ACTIVATORS OF THE UNFOLDED PROTEIN RESPONSE | HSPA5, DDIT3, XBP1 | CES1 2444/4885DAO 3918/4885NSD2 2905/4885 |
| US-11174267-B2 | Spiroindolinones and therapeutic uses thereof | SORD, SDHA, CYP11B2 | CES1 2969/4885DAO 1839/4885NSD2 2771/4885 |
| US-20210340100-A1 | ACTIVATORS OF THE UNFOLDED PROTEIN RESPONSE | HSPA5, DDIT3, XBP1 | CES1 2444/4885DAO 3918/4885NSD2 2905/4885 |
| US-20020016354-A1 | Use of isatin derivatives as ion channel activating agents | KCNN3, KCNJ2, KCND2 | CES1 2526/4885DAO 4786/4885NSD2 2104/4885 |
| US-12180159-B2 | Activators of the unfolded protein response | HSPA5, DDIT3, XBP1 | CES1 2444/4885DAO 3918/4885NSD2 2905/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.