SCHEMBL9516552

SCHEMBL9516552

COc1ccc(C2=C(C#N)c3ccc(OC)cc3CC2)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EGFR P00533 5/20 0.50
ALDH1A1 P00352 3/20 0.48
CYP1A2 P05177 2/20 0.48
MAPT P10636 2/20 0.48
MEN1 O00255 1/20 0.48
LMNA P02545 1/20 0.48
CYP3A4 P08684 1/20 0.48
CYP2C9 P11712 1/20 0.48
KMT2A Q03164 1/20 0.48
ESR1 P03372 2/20 0.43
MAPK1 P28482 1/20 0.43
KDM4E B2RXH2 3/20 0.43
GLA P06280 2/20 0.43
EBP Q15125 1/20 0.42
SIGMAR1 Q99720 1/20 0.42
CYP2D6 P10635 1/20 0.42
MPO P05164 1/20 0.41
CYP19A1 P11511 2/20 0.40
CYP11B2 P19099 2/20 0.40
NR1H2 P55055 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3141978 0.76 MPO (0.54) ALDH1A1CYP1A2MAPTLMNAKDM4E
SCHEMBL9516545 0.74 MIF (0.45) EGFRALDH1A1CYP1A2MAPTLMNA
SCHEMBL9516797 0.74 KDM4E (0.47) EGFRALDH1A1CYP1A2MAPTMEN1
SCHEMBL7284412 0.74 BCL2 (0.49) EGFRALDH1A1CYP1A2MAPTMAPK1
SCHEMBL17108416 0.74 MPO (0.59) ALDH1A1CYP1A2MAPTLMNAKDM4E
SCHEMBL7623247 0.73 ESR1 (0.75) ESR1EBPSIGMAR1
SCHEMBL8468590 0.71 ESR1 (0.55) ALDH1A1MAPTLMNAESR1EBP
SCHEMBL3862097 0.71 ESR1 (0.52) ALDH1A1CYP1A2MAPTMEN1CYP2C9
SCHEMBL3844220 0.71 ESR1 (0.57) ALDH1A1MAPTKMT2AESR1MAPK1
SCHEMBL20031646 0.71 EGFR (0.58) EGFRALDH1A1CYP1A2MAPTMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0394194-B1 PROTECTED AMINO-ACIDS AND PROCESS FOR THEIR PREPARATION CALBIOCHEM-NOVABIOCHEM AG (CH) 1993-08-18 EP claimed
EP-0281283-B1 HETEROCYCLIC COMPOUNDS IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1993-02-10 EP disclosed
US-4910212-A Containing 1,2,4-triazole or imidazole ring IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1990-03-20 US disclosed
EP-0281283-A1 Heterocyclic compounds IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1988-09-07 EP disclosed