Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.37 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 3/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.33 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9515669 | 0.92 | LMNA (0.38) | LMNAPOLBHDAC6GABRA5P4HTM | |
| SCHEMBL9516321 | 0.89 | LMNA (0.39) | LMNAPOLBHDAC6GABRA5P4HTM | |
| SCHEMBL9515835 | 0.86 | LMNA (0.39) | LMNAPOLBHDAC6GABRA5P4HTM | |
| SCHEMBL9516945 | 0.83 | LMNA (0.40) | LMNAPOLBHDAC6GABRA5P4HTM | |
| SCHEMBL9515607 | 0.79 | EPHX2 (0.40) | HDAC6GABRA5P4HTMHDAC3HDAC1 | |
| SCHEMBL9519643 | 0.78 | GRM5 (0.39) | HDAC6GABRA5P4HTMGRM5CASP3 | |
| SCHEMBL9516313 | 0.77 | TLR4 (0.37) | LMNAP4HTM | |
| SCHEMBL9517908 | 0.76 | CXCR1 (0.39) | HDAC6GABRA5P4HTMHDAC3HDAC1 | |
| SCHEMBL9515678 | 0.75 | APLNR (0.40) | LMNAPOLBHDAC6GABRA5P4HTM | |
| SCHEMBL9516269 | 0.75 | P4HTM (0.40) | POLBGABRA5P4HTMNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0567997-A1 | 4- or 5-(sulf)imido- and (sulfon)amidopyridines and their pyridine-N-oxides, process for their preparation and their use as pharmaceutical | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-11-03 | — | — | EP | disclosed |