Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 5/20 | 0.38 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.36 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.35 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.35 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9516262 | 0.90 | GRM5 (0.40) | GRM5CASP3CXCR1CXCR2GABRA5 | |
| SCHEMBL9515607 | 0.89 | EPHX2 (0.40) | CASP3CXCR1CXCR2GABRA5HDAC6 | |
| SCHEMBL9519634 | 0.89 | HDAC1 (0.39) | CASP3HDAC6 | |
| SCHEMBL9517229 | 0.87 | POLB (0.38) | GRM5CASP3CXCR1CXCR2GABRA5 | |
| SCHEMBL9517025 | 0.87 | CASP3 (0.39) | GRM5CASP3HDAC6P4HTMSLC6A9 | |
| SCHEMBL9515669 | 0.85 | LMNA (0.38) | GRM5CASP3CXCR1CXCR2GABRA5 | |
| SCHEMBL9517314 | 0.84 | P4HTM (0.36) | CASP3HDAC6P4HTM | |
| SCHEMBL9519649 | 0.83 | GRM5 (0.38) | GRM5CASP3CXCR1CXCR2GABRA5 | |
| SCHEMBL9517259 | 0.83 | EGFR (0.39) | CASP3GABRA5P4HTM | |
| SCHEMBL9517222 | 0.83 | TRPM8 (0.38) | CASP3HDAC6P4HTM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0567997-A1 | 4- or 5-(sulf)imido- and (sulfon)amidopyridines and their pyridine-N-oxides, process for their preparation and their use as pharmaceutical | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-11-03 | — | — | EP | disclosed |