Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.42 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14510428 | 1.00 | PIN1 (0.50) | PIN1POLBNPSR1SMN1; SMN2ALDH1A1 | |
| SCHEMBL26115378 | 0.87 | LMNA (0.49) | PIN1SMN1; SMN2ALDH1A1RECQLMMP8 | |
| SCHEMBL10745657 | 0.86 | PIN1 (0.53) | PIN1POLBNPSR1SMN1; SMN2ALDH1A1 | |
| SCHEMBL26249289 | 0.85 | CYP1A2 (0.51) | POLBNPSR1SMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL13625401 | 0.84 | PIN1 (0.51) | PIN1POLBNPSR1SMN1; SMN2ALDH1A1 | |
| SCHEMBL6893556 | 0.84 | TSHR (0.49) | POLBNPSR1ALDH1A1MEN1KMT2A | |
| SCHEMBL24130014 | 0.84 | SCN5A (0.52) | NPSR1SMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL30272585 | 0.84 | SCN5A (0.52) | NPSR1SMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL24129753 | 0.84 | MAPK1 (0.48) | POLBNPSR1SMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL10745489 | 0.83 | PIN1 (0.50) | PIN1POLBNPSR1SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12624010-B2 | Dihydrooxazole and thiourea derivatives modulating the NLRP3 inflammasome pathway | AC IMMUNE SA (CH) | 2026-05-12 | — | — | US | disclosed |
| EP-4168395-B1 | DIHYDROOXAZOLE AND THIOUREA OR UREA DERIVATIVES MODULATING THE NLRP3 INFLAMMASOME PATHWAY | AC IMMUNE SA (CH) | 2026-03-25 | — | — | EP | disclosed |
| US-20230250070-A1 | DIHYDROOXAZOLE AND THIOUREA DERIVATIVES MODULATING THE NLRP3 INFLAMMASOME PATHWAY | AC IMMUNE SA (CH) | 2023-08-10 | — | — | US | disclosed |
| US-20230250070-A1 | DIHYDROOXAZOLE AND THIOUREA DERIVATIVES MODULATING THE NLRP3 INFLAMMASOME PATHWAY | AC IMMUNE SA (CH) | 2023-08-10 | — | — | US | disclosed |
| EP-4168395-A1 | DIHYDROOXAZOLE AND THIOUREA OR UREA DERIVATIVES MODULATING THE NLRP3 INFLAMMASOME PATHWAY | AC Immune SA (CH) | 2023-04-26 | — | — | EP | disclosed |
| CN-115768754-A | Dihydrooxazole and thiourea or urea derivatives that modulate NLRP3 inflammasome pathways | AC免疫有限公司 | 2023-03-07 | — | — | CN | disclosed |
| WO-2021255279-A1 | D I H YD ROOXAZO LE AND THIOUREA DERIVATIVES MODULATING THE NLRP3 INFLAMMASOME PATHWAY | AC IMMUNE SA (CH) | 2021-12-23 | — | — | WO | disclosed |
| WO-2021255279-A1 | D I H YD ROOXAZO LE AND THIOUREA DERIVATIVES MODULATING THE NLRP3 INFLAMMASOME PATHWAY | AC IMMUNE SA (CH) | 2021-12-23 | — | — | WO | disclosed |
| US-5219886-A | Cardiovascular disorders, analgesics, enzyme inhibitors | SCHERING CORPORATION (US) | 1993-06-15 | — | — | US | disclosed |
| EP-0393441-B1 | MERCAPTO-ACYLAMINO ACIDS | SCHERING CORPORATION (US) | 1993-05-26 | — | — | EP | disclosed |
| EP-0393441-A1 | Mercapto-acylamino acids | SCHERING CORPORATION (US) | 1990-10-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12624010-B2 | Dihydrooxazole and thiourea derivatives modulating the NLRP3 inflammasome pathway | NOD1, NLRP3, NLRP1 | PIN1 1606/4885POLB 4606/4885NPSR1 2695/4885 |
| US-20230250070-A1 | DIHYDROOXAZOLE AND THIOUREA DERIVATIVES MODULATING THE NLRP3 INFLAMMASOME PATHWAY | NLRP3, NOD1, NLRP1 | PIN1 1613/4885POLB 4721/4885NPSR1 3296/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.