Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.69 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.58 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.57 |
| ▸ | PGR | P06401 | 1/20 | 0.57 |
| ▸ | AR | P10275 | 1/20 | 0.57 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.57 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.56 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.55 |
| ▸ | CDK1 | P06493 | 1/20 | 0.55 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.55 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.55 |
| ▸ | CDK2 | P24941 | 1/20 | 0.55 |
| ▸ | CDK7 | P50613 | 1/20 | 0.55 |
| ▸ | CCNH | P51946 | 1/20 | 0.55 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.55 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.55 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.55 |
| ▸ | CLK1 | P49759 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9516051 | 0.88 | PSEN1 (0.64) | TSHRHSD17B2KMT2ASLC22A12FFAR1 | |
| SCHEMBL9517269 | 0.84 | SLC22A12 (0.60) | TSHRKMT2ASLC22A12ARFFAR1 | |
| SCHEMBL9517147 | 0.83 | PGR (0.54) | KMT2ASLC22A12PGRHDAC1HDAC8 | |
| SCHEMBL9517143 | 0.81 | TSHR (0.61) | TSHRHSD17B2KMT2ANR3C1PGR | |
| SCHEMBL7572806 | 0.81 | NR3C1 (0.69) | TSHRHSD17B2KMT2ANR3C1PGR | |
| SCHEMBL7573925 | 0.80 | HSD17B2 (0.79) | TSHRHSD17B2KMT2ANR3C1PGR | |
| SCHEMBL97543 | 0.80 | NR3C1 (0.67) | TSHRHSD17B2KMT2ANR3C1PGR | |
| SCHEMBL30926704 | 0.79 | GAA (0.57) | TSHRHSD17B2KMT2AFFAR1CDK1 | |
| SCHEMBL27180634 | 0.79 | GAA (0.57) | TSHRHSD17B2KMT2AFFAR1CDK1 | |
| SCHEMBL13248888 | 0.79 | HSD17B2 (0.53) | TSHRHSD17B2KMT2ANR3C1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1079466-A | 4-or 5-(sulphur) acylimino-and (inferior sulphur) amidopyridine and pyridine-N-oxide thereof | HOECHST AG (DE) | 1993-12-15 | — | — | CN | disclosed |
| EP-0567997-A1 | 4- or 5-(sulf)imido- and (sulfon)amidopyridines and their pyridine-N-oxides, process for their preparation and their use as pharmaceutical | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-11-03 | — | — | EP | disclosed |