Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | BCL2L1 | Q07817 | 5/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 5/20 | 0.47 |
| ▸ | P4HTM | Q9NXG6 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | PRKACA | P17612 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9518145 | 0.86 | P4HTM (0.61) | BCL2L1MCL1P4HTM | |
| SCHEMBL9515759 | 0.84 | P4HTM (0.58) | ALDH1A1BCL2L1MCL1P4HTMPTGER4 | |
| SCHEMBL9516970 | 0.83 | BCL2L1 (0.48) | KMT2ASMN1; SMN2BCL2L1MCL1P4HTM | |
| SCHEMBL9517291 | 0.81 | BCL2L1 (0.47) | ALDH1A1KMT2ABCL2L1MCL1P4HTM | |
| SCHEMBL9517172 | 0.79 | BCL2L1 (0.50) | BCL2L1MCL1P4HTM | |
| SCHEMBL9515532 | 0.78 | P4HTM (0.61) | BCL2L1MCL1P4HTM | |
| SCHEMBL9516016 | 0.76 | P4HTM (0.58) | BCL2L1MCL1P4HTM | |
| SCHEMBL9518001 | 0.75 | SMN1; SMN2 (0.55) | ALDH1A1KMT2AGAASMN1; SMN2P4HTM | |
| SCHEMBL9519274 | 0.74 | SCN3A (0.51) | ALDH1A1BCL2L1MCL1P4HTMLMNA | |
| SCHEMBL9517241 | 0.73 | P4HTM (0.61) | BCL2L1MCL1P4HTM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0567997-A1 | 4- or 5-(sulf)imido- and (sulfon)amidopyridines and their pyridine-N-oxides, process for their preparation and their use as pharmaceutical | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-11-03 | — | — | EP | disclosed |