Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 2/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 2/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9518256 | 0.79 | SLC6A4 (0.35) | SIGMAR1ADRA2ASMN1; SMN2NPSR1OPRM1 | |
| Hydrochloric Acid SCHEMBL9515994 | 0.79 | SLC6A2 (0.35) | HTR2ASIGMAR1ADRA2ASMN1; SMN2KDM1A | |
| SCHEMBL25966669 | 0.73 | ADRA2A (0.38) | SIGMAR1ADRA2ASMN1; SMN2KDM1ABACE1 | |
| SCHEMBL9519923 | 0.73 | HTR2A (0.44) | HTR2ASIGMAR1ADRA2ARETKDM1A | |
| Hydrochloric Acid SCHEMBL9518269 | 0.71 | HTR2A (0.43) | HTR2ASIGMAR1ADRA2AKDM1AMAOB | |
| SCHEMBL9180894 | 0.71 | TAAR1 (0.34) | SIGMAR1ADRA2ASMN1; SMN2TAAR1NPSR1 | |
| SCHEMBL8558815 | 0.71 | TAAR1 (0.34) | SIGMAR1ADRA2ASMN1; SMN2TAAR1NPSR1 | |
| SCHEMBL8554610 | 0.71 | SIGMAR1 (0.39) | HTR2ASIGMAR1ADRA2ARETKDM1A | |
| SCHEMBL25970945 | 0.71 | ADRA2A (0.39) | SIGMAR1ADRA2ASMN1; SMN2KDM1ABACE1 | |
| SCHEMBL8556517 | 0.71 | SIGMAR1 (0.39) | HTR2ASIGMAR1ADRA2ARETKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0361577-B1 | TETRAHYDRONAPHTHALENE AND INDANE DERIVATIVES | AKZO N.V. (NL) | 1993-05-05 | — | — | EP | disclosed |
| US-4980354-A | Tetrahydronaphthalene and indane derivatives | AKZO N.V. (NL) | 1990-12-25 | — | — | US | disclosed |
| EP-0361577-A1 | Tetrahydronaphthalene and indane derivatives | AKZO N.V. (NL) | 1990-04-04 | — | — | EP | disclosed |