Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | FABP2 | P12104 | 1/20 | 0.51 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.51 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.51 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.51 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.51 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7441533 | 0.83 | CYP1A2 (0.60) | MAPTSMN1; SMN2PTGS1MEN1KMT2A | |
| SCHEMBL10269902 | 0.81 | PTGS1 (0.55) | MAPTSMN1; SMN2PTGS1MEN1KMT2A | |
| SCHEMBL29473809 | 0.81 | RARB (0.56) | MAPTPTGS1MEN1KMT2AALDH1A1 | |
| SCHEMBL2041007 | 0.81 | RARB (0.56) | MAPTPTGS1MEN1KMT2AALDH1A1 | |
| SCHEMBL11539387 | 0.81 | MAPT (0.59) | MAPTSMN1; SMN2L3MBTL1MEN1KMT2A | |
| SCHEMBL28098468 | 0.80 | MAPT (0.54) | MAPTSMN1; SMN2L3MBTL1AKR1C3AKR1C2 | |
| SCHEMBL28771192 | 0.80 | RAB9A (0.51) | MAPTSMN1; SMN2PTGS1MEN1KMT2A | |
| SCHEMBL30989217 | 0.80 | L3MBTL1 (0.62) | MAPTSMN1; SMN2L3MBTL1ALDH1A1HPGD | |
| SCHEMBL1906865 | 0.80 | L3MBTL1 (0.62) | MAPTSMN1; SMN2L3MBTL1ALDH1A1HPGD | |
| SCHEMBL14241374 | 0.79 | KAT6A (0.50) | MAPTSMN1; SMN2L3MBTL1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114644554-A | Preparation method of (S) -flurbiprofen and intermediate thereof | 上海医药工业研究院 | 2022-06-21 | — | — | CN | disclosed |
| CN-113045532-A | Intermediate for preparing S-flurbiprofen and preparation method and application thereof | 上海医药工业研究院 | 2021-06-29 | — | — | CN | disclosed |
| EP-0034871-B2 | PROCESS FOR PREPARING ESTERS OF ALKANOIC ACIDS VIA REARRANGEMENT OF ALPHA-HALOKETALS | BLASCHIM S.p.A. (IT) | 1993-08-25 | — | — | EP | disclosed |
| EP-0210589-B1 | PROCESS FOR PREPARING OPTICALLY ACTIVE ALPHA-HALOGEN KETALS | ZAMBON S.p.A. (IT) | 1990-09-26 | — | — | EP | disclosed |
| US-4861903-A | Intermediates for preparing optically active carboxylic acids | ZAMBON SPA (IT) | 1989-08-29 | — | — | US | disclosed |
| US-4748253-A | Process for preparing esters of alkanoic acids via rearrangement of alpha-haloketals | BLASINACHIM S.P.A. (IT) | 1988-05-31 | — | — | US | disclosed |
| EP-0210589-A2 | Process for preparing optically active alpha-halogen ketals | ZAMBON S.p.A. (IT) | 1987-02-04 | — | — | EP | disclosed |
| EP-0034871-B1 | PROCESS FOR PREPARING ESTERS OF ALKANOIC ACIDS VIA REARRANGEMENT OF ALPHA-HALOKETALS | BLASCHIM S.p.A. (IT) | 1985-07-31 | — | — | EP | disclosed |
| EP-0034871-A2 | Process for preparing esters of alkanoic acids via rearrangement of alpha-haloketals | BLASCHIM S.p.A. (IT) | 1981-09-02 | — | — | EP | disclosed |
| US-4142054-A | TRIVALENT THALLIUM SALT | THE UPJOHN COMPANY (US) | 1979-02-27 | — | — | US | disclosed |
| US-4135051-A | ENOL ETHER OF AN ARYL ALKYL KETONE WITH A THALLIJM SALT, REGENERATION OF THALLIUM SALT BY ADDING PERACID AND REACTIVE METAL COMPOUND | THE UPJOHN COMPANY (US) | 1979-01-16 | — | — | US | disclosed |
| US-4107439-A | Process for preparing arylalkanoic acid derivatives | THE UPJOHN COMPANY (US) | 1978-08-15 | — | — | US | disclosed |