Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | NQO2 | P16083 | 1/20 | 0.44 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL9518056 | 0.90 | MEN1 (0.52) | MTNR1AMAPTKMT2AMEN1TDP1 | |
| SCHEMBL10920355 | 0.88 | SIGMAR1 (0.55) | MTNR1AMAPTKMT2AMEN1TDP1 | |
| SCHEMBL30420224 | 0.81 | MTNR1A (0.54) | MTNR1AMAPTKMT2AMEN1TDP1 | |
| SCHEMBL11472364 | 0.80 | MTNR1A (0.42) | MTNR1AMAPTKMT2AMEN1SIGMAR1 | |
| Succinic Acid SCHEMBL9517552 | 0.79 | MTNR1A (0.45) | MTNR1AMAPTKMT2AMEN1TDP1 | |
| SCHEMBL9800436 | 0.76 | CYP1A2 (0.58) | MTNR1ATDP1MCL1SIGMAR1NQO2 | |
| SCHEMBL22129565 | 0.75 | TDP1 (0.61) | MTNR1AMAPTKMT2AMEN1TDP1 | |
| Oxalic Acid SCHEMBL9374016 | 0.75 | TRPV1 (0.57) | MAPTKMT2ASIGMAR1ALDH1A1KDM4E | |
| SCHEMBL30900805 | 0.75 | TDP1 (0.61) | MTNR1AMAPTKMT2AMEN1TDP1 | |
| SCHEMBL1616841 | 0.74 | TDP1 (0.59) | MTNR1AMAPTKMT2AMEN1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0318234-B1 | IMPROVEMENTS IN OR RELATING TO SELECTIVE SEROTONIN UPTAKE INHIBITORS | ELI LILLY AND COMPANY (US) | 1993-03-17 | — | — | EP | disclosed |