Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.42 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10920355 | 0.81 | SIGMAR1 (0.55) | MTNR1ATDP1SIGMAR1MEN1KMT2A | |
| Oxalic Acid SCHEMBL9517859 | 0.79 | MTNR1A (0.51) | MTNR1ATDP1SIGMAR1MEN1KMT2A | |
| SCHEMBL2314388 | 0.77 | MEN1 (0.66) | MTNR1ATDP1MEN1KMT2AFFAR1 | |
| SCHEMBL22129565 | 0.75 | TDP1 (0.61) | MTNR1ATDP1MEN1KMT2AFFAR1 | |
| SCHEMBL30900805 | 0.75 | TDP1 (0.61) | MTNR1ATDP1MEN1KMT2AFFAR1 | |
| SCHEMBL1616841 | 0.74 | TDP1 (0.59) | MTNR1ATDP1MEN1KMT2AFFAR1 | |
| SCHEMBL6842066 | 0.74 | TDP1 (0.59) | MTNR1ATDP1MEN1KMT2AFFAR1 | |
| SCHEMBL3732554 | 0.74 | TDP1 (0.59) | MTNR1ATDP1MEN1KMT2AFFAR1 | |
| SCHEMBL710750 | 0.74 | TDP1 (0.59) | MTNR1ATDP1MEN1KMT2AFFAR1 | |
| SCHEMBL29865501 | 0.74 | TDP1 (0.59) | MTNR1ATDP1MEN1KMT2AFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0318234-B1 | IMPROVEMENTS IN OR RELATING TO SELECTIVE SEROTONIN UPTAKE INHIBITORS | ELI LILLY AND COMPANY (US) | 1993-03-17 | — | — | EP | disclosed |