Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | MMP1 | P03956 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.37 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TLR4 | O00206 | 1/20 | 0.37 |
| ▸ | TLR2 | O60603 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9516318 | 0.93 | PPARG (0.37) | SMN1; SMN2MMP1MAPK1LMNAGAA | |
| SCHEMBL9515466 | 0.91 | SMN1; SMN2 (0.38) | SMN1; SMN2MMP1MAPK1LMNAGAA | |
| SCHEMBL9516886 | 0.89 | MMP1 (0.40) | SMN1; SMN2MMP1MAPK1LMNAGAA | |
| SCHEMBL9517265 | 0.86 | EGFR (0.41) | SMN1; SMN2GABRA5 | |
| SCHEMBL9515611 | 0.86 | EPHX2 (0.39) | — | |
| SCHEMBL9517230 | 0.84 | HSD11B1 (0.39) | GAA | |
| SCHEMBL9517963 | 0.83 | TLR4 (0.38) | SMN1; SMN2MMP1MAPK1LMNAGAA | |
| SCHEMBL9517321 | 0.82 | SCN9A (0.37) | SMN1; SMN2ADRB2ADRB1ADRB3BCL2L1 | |
| SCHEMBL9517219 | 0.81 | GABRA5 (0.38) | SMN1; SMN2MMP1MAPK1LMNAGAA | |
| SCHEMBL9516196 | 0.81 | GABRA5 (0.50) | SMN1; SMN2GAAHPGDTLR4TLR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0567997-A1 | 4- or 5-(sulf)imido- and (sulfon)amidopyridines and their pyridine-N-oxides, process for their preparation and their use as pharmaceutical | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-11-03 | — | — | EP | disclosed |