Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | P4HTM | Q9NXG6 | 3/20 | 0.36 |
| ▸ | APLNR | P35414 | 2/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.34 |
| ▸ | FLT4 | P35916 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9517321 | 0.91 | SCN9A (0.37) | EGFRSCN9ASCN5ASMN1; SMN2P4HTM | |
| SCHEMBL9515611 | 0.90 | EPHX2 (0.39) | P4HTMAPLNRHDAC1HDAC6 | |
| SCHEMBL9517939 | 0.89 | EGFR (0.40) | EGFRSCN9ASCN5ASMN1; SMN2P4HTM | |
| SCHEMBL9517230 | 0.87 | HSD11B1 (0.39) | P4HTMHDAC1HDAC8HDAC6 | |
| SCHEMBL9517971 | 0.86 | SMN1; SMN2 (0.38) | SMN1; SMN2GABRA5 | |
| SCHEMBL9516977 | 0.86 | EGFR (0.44) | EGFRP4HTMFLT1FLT4KDR | |
| SCHEMBL9515738 | 0.84 | P4HTM (0.43) | EGFRSCN9ASCN5ASMN1; SMN2P4HTM | |
| SCHEMBL9519649 | 0.82 | GRM5 (0.38) | P4HTMGABRA5HDAC6 | |
| SCHEMBL9517259 | 0.82 | EGFR (0.39) | EGFRSCN9ASCN5ASMN1; SMN2P4HTM | |
| SCHEMBL9519641 | 0.80 | SCD (0.41) | HDAC1HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0567997-A1 | 4- or 5-(sulf)imido- and (sulfon)amidopyridines and their pyridine-N-oxides, process for their preparation and their use as pharmaceutical | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-11-03 | — | — | EP | disclosed |