Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 3/20 | 0.56 |
| ▸ | GCGR | P47871 | 6/20 | 0.42 |
| ▸ | AR | P10275 | 2/20 | 0.41 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.38 |
| ▸ | CACNG8 | Q8WXS5 | 1/20 | 0.38 |
| ▸ | CACNG2 | Q9Y698 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9518614 | 0.85 | HMGCR (0.48) | HMGCRGCGRALDH1A1TDP1L3MBTL1 | |
| SCHEMBL9750959 | 0.73 | ABCB1 (0.49) | HMGCRMEN1ALDH1A1GLAMAPT | |
| SCHEMBL9518519 | 0.73 | HMGCR (0.54) | HMGCRARALDH1A1TDP1L3MBTL1 | |
| SCHEMBL9750820 | 0.73 | AR (0.71) | HMGCRARMEN1ALDH1A1MAPT | |
| SCHEMBL9750922 | 0.72 | HMGCR (0.55) | HMGCRARMEN1ALDH1A1KMT2A | |
| SCHEMBL9521513 | 0.72 | HMGCR (0.55) | HMGCRARMEN1ALDH1A1KMT2A | |
| SCHEMBL9751001 | 0.72 | HMGCR (1.00) | HMGCR | |
| SCHEMBL9518354 | 0.71 | AR (0.48) | HMGCRARMEN1ALDH1A1MAPT | |
| SCHEMBL17911742 | 0.71 | KMT2A (0.52) | ARMEN1ALDH1A1KMT2APTGS2 | |
| SCHEMBL10514975 | 0.70 | TAAR1 (0.48) | MEN1ALDH1A1MAPTHPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0300249-B1 | 7-[1H-pyrrol-3-yl]-substituted 3,5-dihydroxy-heptane acids, their corresponding delta-lactones and salts, processes for their manufacture, their use as medicines, pharmaceutical preparations and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-02-03 | — | — | EP | disclosed |
| US-5055484-A | Anticholesterol and antilipemic agent | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-10-08 | — | — | US | disclosed |
| EP-0300249-A1 | 7-[1H-pyrrol-3-yl]-substituted 3,5-dihydroxy-heptane acids, their corresponding delta-lactones and salts, processes for their manufacture, their use as medicines, pharmaceutical preparations and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-01-25 | — | — | EP | disclosed |