Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | GCGR | P47871 | 11/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9518489 | 0.85 | HMGCR (0.56) | HMGCRALDH1A1TDP1L3MBTL1GCGR | |
| SCHEMBL9750893 | 0.80 | KDM4E (0.52) | HMGCRKDM4EALDH1A1TDP1L3MBTL1 | |
| SCHEMBL9518289 | 0.77 | HMGCR (0.47) | HMGCRKDM4EALDH1A1TDP1L3MBTL1 | |
| SCHEMBL9751023 | 0.76 | HMGCR (0.83) | HMGCR | |
| SCHEMBL9750867 | 0.75 | HMGCR (0.66) | HMGCR | |
| SCHEMBL9750808 | 0.75 | HMGCR (0.51) | HMGCRKDM4EALDH1A1TDP1L3MBTL1 | |
| SCHEMBL9658391 | 0.74 | GCGR (0.43) | HMGCRKDM4EALDH1A1TDP1L3MBTL1 | |
| SCHEMBL9750928 | 0.74 | HMGCR (0.55) | HMGCR | |
| SCHEMBL9518442 | 0.74 | HMGCR (0.51) | HMGCRKDM4EALDH1A1TDP1L3MBTL1 | |
| SCHEMBL9750902 | 0.73 | HMGCR (0.46) | HMGCRKDM4EALDH1A1TDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0300249-B1 | 7-[1H-pyrrol-3-yl]-substituted 3,5-dihydroxy-heptane acids, their corresponding delta-lactones and salts, processes for their manufacture, their use as medicines, pharmaceutical preparations and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-02-03 | — | — | EP | disclosed |
| US-5055484-A | Anticholesterol and antilipemic agent | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-10-08 | — | — | US | disclosed |
| EP-0300249-A1 | 7-[1H-pyrrol-3-yl]-substituted 3,5-dihydroxy-heptane acids, their corresponding delta-lactones and salts, processes for their manufacture, their use as medicines, pharmaceutical preparations and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-01-25 | — | — | EP | disclosed |