Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | ERN1 | O75460 | 2/20 | 0.40 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9518445 | 0.83 | IDO1 (0.41) | ERN1ALOX5PTGS2MAPTKDM4E | |
| SCHEMBL31359247 | 0.82 | PTGDR2 (0.33) | PDE4APDE4BPDE4CPDE4DMCL1 | |
| SCHEMBL3467837 | 0.79 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DMCL1 | |
| SCHEMBL1832013 | 0.79 | ERN1 (0.46) | ERN1MAPTKDM4EALDH1A1HSD17B10 | |
| SCHEMBL30829272 | 0.77 | CA2 (0.47) | PDE4APDE4BPDE4CPDE4DPDCD1 | |
| SCHEMBL30505690 | 0.77 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DMCL1 | |
| SCHEMBL147850 | 0.77 | CA2 (0.47) | PDE4APDE4BPDE4CPDE4DPDCD1 | |
| SCHEMBL31432590 | 0.75 | HIF1A (0.53) | ERN1ALOX5PTGS2MAPTKDM4E | |
| SCHEMBL7674886 | 0.74 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4DPDCD1 | |
| SCHEMBL10557023 | 0.74 | SHBG (0.39) | PDCD1CD274KDM4EALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0269599-B1 | Substituted 1H-imidazoles | UCB SA (BE) | 1993-12-15 | — | — | EP | disclosed |
| US-4814343-A | ANTIISCHEMIC | U C B, S.A. (BE) | 1989-03-21 | — | — | US | disclosed |
| EP-0269599-A2 | Substituted 1H-imidazoles | U C B, S.A. (BE) | 1988-06-01 | — | — | EP | disclosed |