Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9517061 | 0.88 | POLB (0.49) | EPHX2POLBTDP1NPC1RAB9A | |
| SCHEMBL9516006 | 0.88 | MEN1 (0.37) | MEN1CYP1A2CYP3A4KMT2A | |
| SCHEMBL9517052 | 0.84 | EPHX2 (0.50) | EPHX2POLBTDP1NPC1RAB9A | |
| SCHEMBL9516196 | 0.78 | GABRA5 (0.50) | KDM4EHCAR3SMN1; SMN2MAPT | |
| SCHEMBL9515509 | 0.78 | NPC1 (0.50) | POLBTDP1NPC1RAB9AKDM4E | |
| SCHEMBL14819065 | 0.77 | ALDH1A1 (0.42) | TDP1KDM4EHDAC1SMN1; SMN2HTT | |
| SCHEMBL9566843 | 0.75 | TRPV1 (0.54) | POLBNPC1RAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL9516137 | 0.75 | HDAC3 (0.45) | POLBTDP1NPC1RAB9AHDAC3 | |
| SCHEMBL9517267 | 0.75 | EPHX1 (0.51) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL11622756 | 0.74 | MAPT (0.52) | EPHX2POLBTDP1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0567997-A1 | 4- or 5-(sulf)imido- and (sulfon)amidopyridines and their pyridine-N-oxides, process for their preparation and their use as pharmaceutical | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-11-03 | — | — | EP | disclosed |