Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTAFR | P25105 | 7/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 6/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9519510 | 1.00 | PTAFR (0.46) | PTAFRPDE4BCNR1HDAC3HDAC1 | |
| SCHEMBL9520661 | 0.99 | PTAFR (0.47) | PTAFRPDE4BCNR1HDAC3HDAC1 | |
| SCHEMBL9521062 | 0.99 | PTAFR (0.47) | PTAFRPDE4BCNR1HDAC3HDAC1 | |
| SCHEMBL9519702 | 0.99 | PTAFR (0.47) | PTAFRPDE4BCNR1HDAC3HDAC1 | |
| SCHEMBL9520959 | 0.96 | PDE4B (0.46) | PTAFRPDE4BCNR1HDAC3HDAC1 | |
| SCHEMBL9520765 | 0.91 | PDE4B (0.44) | PTAFRPDE4BHDAC3HDAC1HDAC2 | |
| SCHEMBL9520013 | 0.85 | CA1 (0.45) | PTAFRPDE4BHDAC3HDAC1HDAC2 | |
| SCHEMBL10399227 | 0.85 | PTAFR (0.52) | PTAFRPDE4BCNR1HDAC3HDAC1 | |
| Bicarbonate SCHEMBL9519703 | 0.85 | PTAFR (0.48) | PTAFRPDE4BCNR1HDAC3HDAC1 | |
| SCHEMBL9519486 | 0.85 | HTR7 (0.47) | HDAC3HDAC1HDAC2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0299379-B1 | PENTADIENAMIDE PAF-ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1993-04-21 | — | — | EP | disclosed |
| EP-0299379-A1 | Pentadienamide PAF-antagonists | F. HOFFMANN-LA ROCHE AG (CH) | 1989-01-18 | — | — | EP | disclosed |