Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | PTAFR | P25105 | 7/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 2/20 | 0.40 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.40 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.40 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.40 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9519700 | 0.96 | PTAFR (0.46) | PDE4BPTAFRKDM4ECRHBPHTT | |
| SCHEMBL9519510 | 0.96 | PTAFR (0.46) | PDE4BPTAFRKDM4ECRHBPHTT | |
| SCHEMBL9521062 | 0.95 | PTAFR (0.47) | PDE4BPTAFRHDAC3HDAC1HDAC2 | |
| SCHEMBL9519702 | 0.95 | PTAFR (0.47) | PDE4BPTAFRHDAC3HDAC1HDAC2 | |
| SCHEMBL9520661 | 0.95 | PTAFR (0.47) | PDE4BPTAFRHDAC3HDAC1HDAC2 | |
| SCHEMBL9520765 | 0.92 | PDE4B (0.44) | PDE4BPTAFRHDAC3HDAC1HDAC2 | |
| SCHEMBL9520013 | 0.87 | CA1 (0.45) | PDE4BPTAFRHDAC3HDAC1HDAC2 | |
| SCHEMBL9520878 | 0.85 | TAS1R3 (0.44) | TAS1R3TAS1R1PARP1NPC1RAB9A | |
| SCHEMBL9521201 | 0.85 | TAS1R3 (0.44) | TAS1R3TAS1R1PARP1NPC1RAB9A | |
| Bicarbonate SCHEMBL9520966 | 0.84 | PTAFR (0.47) | PDE4BPTAFRKDM4ECRHBPHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0299379-B1 | PENTADIENAMIDE PAF-ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1993-04-21 | — | — | EP | disclosed |
| EP-0299379-A1 | Pentadienamide PAF-antagonists | F. HOFFMANN-LA ROCHE AG (CH) | 1989-01-18 | — | — | EP | disclosed |