Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTAFR | P25105 | 6/20 | 0.47 |
| ▸ | CNR1 | P21554 | 4/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9520661 | 1.00 | PTAFR (0.47) | PTAFRCNR1PDE4BCNR2TP53 | |
| SCHEMBL9521062 | 1.00 | PTAFR (0.47) | PTAFRCNR1PDE4BCNR2TP53 | |
| SCHEMBL9519700 | 0.99 | PTAFR (0.46) | PTAFRCNR1PDE4BCNR2HDAC1 | |
| SCHEMBL9519510 | 0.99 | PTAFR (0.46) | PTAFRCNR1PDE4BCNR2HDAC1 | |
| SCHEMBL9520959 | 0.95 | PDE4B (0.46) | PTAFRCNR1PDE4BCNR2HDAC1 | |
| SCHEMBL9520765 | 0.90 | PDE4B (0.44) | PTAFRPDE4BHDAC1HDAC8HDAC3 | |
| Bicarbonate SCHEMBL9520666 | 0.85 | PTAFR (0.48) | PTAFRCNR1PDE4BTP53TSHR | |
| Bicarbonate SCHEMBL9519706 | 0.85 | PTAFR (0.48) | PTAFRCNR1PDE4BTP53TSHR | |
| SCHEMBL10398954 | 0.85 | PTAFR (0.53) | PTAFRCNR1PDE4BCNR2TP53 | |
| SCHEMBL10399183 | 0.85 | PTAFR (0.53) | PTAFRCNR1PDE4BCNR2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0299379-B1 | PENTADIENAMIDE PAF-ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1993-04-21 | — | — | EP | disclosed |
| EP-0299379-A1 | Pentadienamide PAF-antagonists | F. HOFFMANN-LA ROCHE AG (CH) | 1989-01-18 | — | — | EP | disclosed |