Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOX | P28300 | 1/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 2/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.36 |
| ▸ | PLK1 | P53350 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | NOS3 | P29474 | 2/20 | 0.31 |
| ▸ | NOS1 | P29475 | 2/20 | 0.31 |
| ▸ | NOS2 | P35228 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20073811 | 0.85 | LOX (0.43) | LOXLOXL2RXRAGRIN1GRIN2B | |
| SCHEMBL4018107 | 0.83 | LOXL2 (0.59) | LOXLOXL2MAOADYRK1APDE1B | |
| SCHEMBL4024225 | 0.79 | LOX (0.50) | LOXLOXL2MAOADYRK1AADAM17 | |
| SCHEMBL29183339 | 0.79 | AR (0.44) | LOXLOXL2ARMAOB | |
| SCHEMBL4020008 | 0.77 | LOXL2 (0.44) | LOXLOXL2MAOADYRK1ANOS3 | |
| SCHEMBL4019820 | 0.74 | LOXL2 (0.41) | LOXLOXL2HCRTR1HCRTR2MAOA | |
| SCHEMBL4017623 | 0.73 | GABRA5 (0.42) | LOXLOXL2MAOB | |
| SCHEMBL30753303 | 0.73 | NOS3 (0.40) | LOXLOXL2ARMAOBNOS3 | |
| SCHEMBL31451327 | 0.72 | NOS3 (0.33) | MAOBNOS3NOS1NOS2 | |
| SCHEMBL511200 | 0.71 | IDO1 (0.56) | MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0282077-B1 | Pyridyloxy derivatives | FUJIREBIO KK (JP) | 1993-11-10 | — | — | EP | disclosed |
| US-4977267-A | ANTISECRETORY AGENT | FUJIREBIO KABUSHIKI KAISHA (JP) | 1990-12-11 | — | — | US | disclosed |
| US-4912101-A | Containing a secondary amide, suflur group and a furan ring | FUJIREBIO KABUSHIKI KAISHA (JP) | 1990-03-27 | — | — | US | disclosed |
| EP-0282077-A2 | Pyridyloxy derivatives | FUJIREBIO KABUSHIKI KAISHA (JP) | 1988-09-14 | — | — | EP | disclosed |