Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 2/20 | 0.47 |
| ▸ | CES1 | P23141 | 2/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.45 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | PTAFR | P25105 | 3/20 | 0.42 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9520329 | 1.00 | CES2 (0.47) | CES2CES1PARP1GPR52TBXAS1 | |
| SCHEMBL9519518 | 0.89 | NPC1 (0.54) | CES2CES1PARP1GPR52PTAFR | |
| SCHEMBL9520665 | 0.89 | NPC1 (0.54) | CES2CES1PARP1GPR52PTAFR | |
| SCHEMBL9521627 | 0.82 | PAM (0.50) | CES2CES1PARP1TBXAS1PTAFR | |
| SCHEMBL9520140 | 0.82 | PAM (0.50) | CES2CES1PARP1TBXAS1PTAFR | |
| SCHEMBL9519281 | 0.82 | ERCC5 (0.45) | PARP1PTAFRMEN1KMT2AKCNK3 | |
| SCHEMBL9520834 | 0.82 | ERCC5 (0.45) | PARP1PTAFRMEN1KMT2AKCNK3 | |
| SCHEMBL9520579 | 0.81 | CES2 (0.51) | CES2TBXAS1KCNK3HPGDLMNA | |
| SCHEMBL9519800 | 0.81 | CES2 (0.51) | CES2TBXAS1KCNK3HPGDLMNA | |
| SCHEMBL9521054 | 0.81 | CES2 (0.41) | CES2CES1TBXAS1PTAFRNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0299379-B1 | PENTADIENAMIDE PAF-ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1993-04-21 | — | — | EP | disclosed |
| EP-0299379-A1 | Pentadienamide PAF-antagonists | F. HOFFMANN-LA ROCHE AG (CH) | 1989-01-18 | — | — | EP | disclosed |