Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC5 | P28715 | 1/20 | 0.45 |
| ▸ | FEN1 | P39748 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | PTAFR | P25105 | 2/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.40 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PAM | P19021 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9520834 | 1.00 | ERCC5 (0.45) | ERCC5FEN1PARP1MEN1KMT2A | |
| SCHEMBL9520140 | 0.82 | PAM (0.50) | PARP1MEN1KMT2APTAFRALDH1A1 | |
| SCHEMBL9521627 | 0.82 | PAM (0.50) | PARP1MEN1KMT2APTAFRALDH1A1 | |
| SCHEMBL9519797 | 0.82 | CES2 (0.47) | PARP1MEN1KMT2APTAFRKCNK3 | |
| SCHEMBL9520329 | 0.82 | CES2 (0.47) | PARP1MEN1KMT2APTAFRKCNK3 | |
| SCHEMBL9519681 | 0.81 | ALOX15 (0.44) | ERCC5FEN1PTAFRALDH1A1MAPT | |
| SCHEMBL9522078 | 0.81 | ALOX15 (0.44) | ERCC5FEN1PTAFRALDH1A1MAPT | |
| SCHEMBL10397702 | 0.80 | PARP1 (0.49) | ERCC5FEN1PARP1PTAFRMAOB | |
| SCHEMBL10397703 | 0.80 | PARP1 (0.49) | ERCC5FEN1PARP1PTAFRMAOB | |
| SCHEMBL10398588 | 0.80 | PARP1 (0.49) | ERCC5FEN1PARP1PTAFRMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0299379-B1 | PENTADIENAMIDE PAF-ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1993-04-21 | — | — | EP | disclosed |
| EP-0299379-A1 | Pentadienamide PAF-antagonists | F. HOFFMANN-LA ROCHE AG (CH) | 1989-01-18 | — | — | EP | disclosed |