Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAM | P19021 | 1/20 | 0.50 |
| ▸ | PTAFR | P25105 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9521627 | 1.00 | PAM (0.50) | PAMPTAFRALDH1A1ALOX15CYP2D6 | |
| SCHEMBL9521278 | 0.90 | SMN1; SMN2 (0.46) | PAMPTAFRALDH1A1MAPTTSHR | |
| SCHEMBL9522407 | 0.86 | CES2 (0.53) | PTAFRALDH1A1CYP3A4MAPTPARP1 | |
| SCHEMBL9523136 | 0.86 | CES2 (0.53) | PTAFRALDH1A1CYP3A4MAPTPARP1 | |
| SCHEMBL9519681 | 0.84 | ALOX15 (0.44) | PAMPTAFRALDH1A1ALOX15MAPT | |
| SCHEMBL9522078 | 0.84 | ALOX15 (0.44) | PAMPTAFRALDH1A1ALOX15MAPT | |
| SCHEMBL9521054 | 0.84 | CES2 (0.41) | PAMPTAFRALDH1A1ALOX15CYP2D6 | |
| SCHEMBL9519790 | 0.84 | KMT2A (0.44) | PAMPTAFRALDH1A1TDP1MAPT | |
| SCHEMBL9522756 | 0.83 | MTNR1A (0.55) | ALDH1A1PARP1MTNR1AMTNR1BCES1 | |
| SCHEMBL9519841 | 0.83 | MTNR1A (0.55) | ALDH1A1PARP1MTNR1AMTNR1BCES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0299379-B1 | PENTADIENAMIDE PAF-ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1993-04-21 | — | — | EP | disclosed |
| EP-0299379-A1 | Pentadienamide PAF-antagonists | F. HOFFMANN-LA ROCHE AG (CH) | 1989-01-18 | — | — | EP | disclosed |