Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 3/20 | 0.74 |
| ▸ | HTR2A | P28223 | 1/20 | 0.74 |
| ▸ | HTR2B | P41595 | 1/20 | 0.74 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.65 |
| ▸ | DRD2 | P14416 | 4/20 | 0.63 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.63 |
| ▸ | DRD3 | P35462 | 3/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | THPO | P40225 | 1/20 | 0.59 |
| ▸ | MTOR | P42345 | 1/20 | 0.59 |
| ▸ | BLM | P54132 | 1/20 | 0.59 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9519068 | 0.93 | ALDH1A1 (0.69) | HTR2CHTR2AHTR2BSIGMAR1DRD2 | |
| SCHEMBL10520491 | 0.84 | SIGMAR1 (0.56) | HTR2CHTR2AHTR2BSIGMAR1DRD2 | |
| SCHEMBL9518868 | 0.83 | SIGMAR1 (0.62) | HTR2CHTR2AHTR2BSIGMAR1DRD2 | |
| SCHEMBL10519108 | 0.81 | DRD2 (0.54) | HTR2CHTR2AHTR2BSIGMAR1DRD2 | |
| SCHEMBL9521505 | 0.81 | DRD2 (0.64) | HTR2CHTR2AHTR2BSIGMAR1DRD2 | |
| SCHEMBL6619322 | 0.80 | ALDH1A1 (0.71) | HTR2CHTR2ASIGMAR1DRD2ALDH1A1 | |
| SCHEMBL9378627 | 0.80 | SIGMAR1 (1.00) | HTR2CSIGMAR1DRD2ADRA1ADRD3 | |
| SCHEMBL10518728 | 0.79 | HTR1A (0.56) | HTR2CHTR2AHTR2BSIGMAR1DRD2 | |
| SCHEMBL4928954 | 0.77 | DRD2 (1.00) | HTR2CHTR2ASIGMAR1DRD2ADRA1A | |
| SCHEMBL9518921 | 0.77 | HTR2A (0.73) | HTR2CHTR2AHTR2BDRD2ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-63060978-A | — | — | None | — | — | JP | disclosed |
| EP-0279598-B1 | ARYLPIPERAZINYL-ALKYLENE-PHENYL-HETEROCYCLIC COMPOUNDS | PFIZER INC. (US) | 1993-09-15 | — | — | EP | disclosed |
| US-4891375-A | Arylpiperazinyl-alkylene-phenyl-heterocyclic compounds | PFIZER INC. (US) | 1990-01-02 | — | — | US | disclosed |
| EP-0279598-A2 | Arylpiperazinyl-alkylene-phenyl-heterocyclic compounds | PFIZER INC. (US) | 1988-08-24 | — | — | EP | disclosed |
| EP-0263782-A1 | Esters of allyl-bicyclo[2,2,1]-hept-5-ene-2-carboxylic acid and their polymers | CIBA-GEIGY AG (CH) | 1988-04-13 | — | — | EP | disclosed |
| JP-S6360978-A | AMINOTHIAZOLE COMPOUND | YOSHITOMI PHARMACEUT IND LTD | 1988-03-17 | — | — | JP | disclosed |