Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 5/20 | 0.51 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.44 |
| ▸ | HTR1B | P28222 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTR1D | P28221 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25942819 | 0.90 | LTA4H (0.50) | LTA4HTAAR1ALDH1A1KCNH2CYP1A2 | |
| SCHEMBL15226903 | 0.89 | ESRRB (0.52) | LTA4HLMNAALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL14558318 | 0.85 | PKM (0.58) | LTA4HHTT | |
| SCHEMBL6443597 | 0.79 | LTA4H (0.75) | LTA4HKCNA3CHRNB2CHRNA4LMNA | |
| SCHEMBL12744959 | 0.78 | LTA4H (0.58) | LTA4HKCNA3CHRNB2CHRNA4HTR1B | |
| SCHEMBL11677652 | 0.76 | LTA4H (0.59) | LTA4HKCNA3TAAR1HTR1BLMNA | |
| SCHEMBL27010001 | 0.75 | LTA4H (0.51) | LTA4HKCNA3CHRNB2CHRNA4HTR1B | |
| SCHEMBL8959902 | 0.75 | TAAR1 (0.49) | TAAR1LMNAALDH1A1KCNH2HTT | |
| SCHEMBL10526844 | 0.75 | KCNA3 (0.56) | LTA4HKCNA3TAAR1HTR1BHTR1D | |
| SCHEMBL27840492 | 0.74 | TAAR1 (0.49) | TAAR1LMNAALDH1A1KCNH2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0507863-A4 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | — | 1993-07-07 | — | — | EP | disclosed |
| EP-0507863-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1992-10-14 | — | — | EP | disclosed |