SCHEMBL9522305

SCHEMBL9522305

COc1ccc(Br)c(F)c1N1CCN(C)CC1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.46
MAPK1 P28482 1/20 0.46
DRD2 P14416 3/20 0.45
DRD3 P35462 2/20 0.45
HTR6 P50406 4/20 0.43
HTR2A P28223 3/20 0.40
HTR1D P28221 2/20 0.40
HTR1B P28222 2/20 0.40
ALDH1A1 P00352 2/20 0.39
KDM4E B2RXH2 1/20 0.39
HPGD P15428 1/20 0.39
TSHR P16473 1/20 0.39
CASP1 P29466 1/20 0.39
CASP7 P55210 1/20 0.39
CYP1A2 P05177 3/20 0.38
CYP2D6 P10635 3/20 0.38
CYP3A4 P08684 2/20 0.38
CYP2C19 P33261 2/20 0.38
HTR1A P08908 2/20 0.38
HTR7 P34969 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21590165 0.83 MAPT (0.47) MAPTMAPK1DRD2DRD3HTR6
SCHEMBL21447973 0.78 DRD3 (0.56) MAPTMAPK1DRD2DRD3HTR2A
SCHEMBL9523246 0.74 DRD3 (0.56) MAPK1DRD2DRD3HTR6HTR2A
SCHEMBL21590174 0.72 GAA (0.46) MAPTMAPK1DRD2DRD3HTR6
SCHEMBL9525829 0.72 MAPT (0.41) MAPTMAPK1DRD2DRD3HTR6
SCHEMBL28513873 0.71 GAA (0.51) MAPTMAPK1DRD2DRD3HTR6
SCHEMBL2384047 0.71 SIRT6 (0.58) MAPTMAPK1DRD2DRD3HTR6
SCHEMBL21448007 0.70 HRH4 (0.42) MAPTDRD2DRD3HTR6HTR2A
SCHEMBL21388456 0.70 MAPT (0.43) MAPTMAPK1DRD2DRD3HTR2A
SCHEMBL27565044 0.70 DRD2 (0.46) MAPTMAPK1DRD2DRD3HTR6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0249043-B1 QUINOLINECARBOXYLIC ACID DERIVATIVES NIPPON SHINYAKU COMPANY, LIMITED (JP) 1993-08-04 EP disclosed
US-5086049-A Bactericides NIPPONSHINYAKU CO., LTD. (JP) 1992-02-04 US disclosed
US-4843070-A BACTERIDCIDES, FUNGICIDES NIPPON SHINYAKU CO., LTD. (JP) 1989-06-27 US disclosed
EP-0249043-A2 Quinolinecarboxylic acid derivatives NIPPON SHINYAKU COMPANY, LIMITED (JP) 1987-12-16 EP disclosed